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Environmental Geochemistry and Health

, Volume 38, Issue 1, pp 265–274 | Cite as

Correlation of cadmium and aluminum in blood samples of kidney disorder patients with drinking water and tobacco smoking: related health risk

  • Abdul Haleem Panhwar
  • Tasneem Gul Kazi
  • Hassan Imran Afridi
  • Salma Aslam Arain
  • Mariam Shahzadi Arain
  • Kapil Dev Brahaman
  • Naeemullah
  • Sadaf Sadia Arain
Original Paper

Abstract

The combined exposure to aluminum (Al) and cadmium (Cd) causes more pronounced adverse health effects on humans. The kidneys are the main organs affected by internal exposure to Cd and Al via food and non-food items. The objective of present study was to measure the Al and Cd concentrations in cigarettes tobacco (branded and non-branded) and drinking water (domestic treated, ground and lake water) samples in southern part of Pakistan, to assess the risk due to ingestion of water and inhalation of cigarettes smoke containing high concentrations of both elements. The study population (kidney disorder and healthy) divided into two group based on consuming lake and ground water, while smoking non-branded cigarette as exposed, while drinking domestic treated water and smoking branded cigarette as non-exposed. Electrothermal atomic absorption spectrometry was used to determined Cd and Al concentrations in tobacco, drinking water and blood samples. The resulted data indicated that the levels of Al and Cd in lake and underground water were higher than the permissible limit in drinking water recommended by the World Health Organization. The biochemical parameters of exposed and referent patients, especially urinary N-acetyl-h-glucosaminidase, were used as a biomarkers of kidney disorder. Exposed kidney disorder patients have higher levels of Cd and Al than the exposed referents subjects, while difference was significant when compared to resulted data of non-exposed patients and referents (p = 0.01–0.001). The pearson correlation showed positive correlation between both toxic element concentrations in water, cigarettes versus blood samples of exposed subjects (r = 0.20–0.67 and 0.71–0.82), while lower values were observed for non-exposed subjects (r = 0.123–0.423 and 0.331–0.425), respectively.

Keywords

Cadmium Aluminum Kidney disorders Drinking water Tobacco smoking Blood 

Notes

Acknowledgments

The authors are thankful to the National Center of Excellence in Analytical Chemistry university of Sindh Pakistan for sponsoring this project.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Abdul Haleem Panhwar
    • 1
  • Tasneem Gul Kazi
    • 1
  • Hassan Imran Afridi
    • 1
  • Salma Aslam Arain
    • 1
  • Mariam Shahzadi Arain
    • 1
  • Kapil Dev Brahaman
    • 1
  • Naeemullah
    • 1
  • Sadaf Sadia Arain
    • 1
  1. 1.National Centre of Excellence in Analytical ChemistryUniversity of SindhJamshoroPakistan

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