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Effect of dietary cadmium on lipid metabolism and storage of aquatic bird Cairina moschata

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Abstract

In environment, birds often fast in connection with breeding, migration or drastic climatic conditions and need to mobilize lipid reserves during these periods. The impairment of lipid metabolism by cadmium (Cd; 1 mg kg−1 added in diet) was investigated on palmiped Cairina moschata. Expression levels of genes involved in lipid metabolism, mitochondrial metabolism and detoxification were investigated in liver and muscle of ducks. Lipid content in muscle and liver were analysed and plasma triglycerides were quantified. After 20 days, ducks exposed to Cd displayed a lower body weight and lower lipid content in liver than controls. In muscle, the increase of lipid content was only significant for control ducks but not for exposed ducks. Exposed ducks appeared unable to sufficiently transport and store lipids into peripheral tissues. Cd impairs lipid metabolism by several ways. First, Cd triggered the down-regulation of fatty acids synthesis in liver even if the NADPH production and the mitochondrial metabolism are enhanced, suggesting a stronger energy needs. Secondly, the associated decrease of plasma triglycerides and lipoprotein lipase activity with Cd are consistent with impairment of lipids storage in peripheral tissues.

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Acknowledgments

The authors would like to thank the Conseil Général des Landes (France) for their financial support and the INRA of Artiguères for technical help.

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Authors and Affiliations

  1. IPREM-EEM (Institut Pluridisciplinaire de Recherche sur l’Environnement et les Matériaux, Equipe Environnement et Microbiologie), UMR 5254, IUT des Pays de l’Adour, 371 rue du ruisseau, BP 201, 40004, Mont de Marsan Cedex, France

    Magali Lucia, Jean-Marc André, Karine Gontier & Stéphane Davail

  2. UMR 5805 EPOC, Team GEMA, Université Bordeaux 1 and CNRS, Place du Dr Peyneau, 33120, Arcachon, France

    Patrice Gonzalez, Magalie Baudrimont & Régine Maury-Brachet

  3. INRA, Artiguères, 40280, Benquet, France

    Marie-Dominique Bernadet & Gérard Guy

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  1. Magali Lucia
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  2. Jean-Marc André
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Correspondence to Magali Lucia.

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Lucia, M., André, JM., Gonzalez, P. et al. Effect of dietary cadmium on lipid metabolism and storage of aquatic bird Cairina moschata . Ecotoxicology 19, 163–170 (2010). https://doi.org/10.1007/s10646-009-0401-7

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  • DOI: https://doi.org/10.1007/s10646-009-0401-7

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