Abstract
Ecotoxicological models generally have large data requirements and are frequently based on existing information from diverse sources. Standardizing data for toxicological models may be necessary to reduce extraneous variation and to ensure models reflect intrinsic relationships. However, the extent to which data standardization is necessary remains unclear, particularly when data transformations are used in model development. An extensive acute toxicity database was compiled for aquatic species to comprehensively assess the variation associated with acute toxicity test type (e.g., flow-through, static), reporting concentrations as nominal or measured, and organism life stage. Three approaches were used to assess the influence of these factors on log-transformed acute toxicity: toxicity ratios, log-linear models of factor groups, and comparison of interspecies correlation estimation (ICE) models developed using either standardized test types or reported concentration type. In general, median ratios were generally less than 2.0, the slopes of log-linear models were approximately one for well-represented comparisons, and ICE models developed using data from standardized test types or reported concentrations did not differ substantially. These results indicate that standardizing test data by acute test type, reported concentration type, or life stage may not be critical for developing ecotoxicological models using large datasets of log-transformed values.
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References
Asfaw A, Ellersieck MR, Mayer FL (2003) Interspecies correlation estimations (ICE) for acute toxicity to aquatic organisms and wildlife. II. User manual and software. United States Environmental Protection Agency, Washington EPA/600/R-03/106
ASTM (1980) Practice for conducting acute toxicity tests with fishes, macroinvertebrates, and amphibians. American society for test and materials, Philadelphia, pp 729–780
ASTM (2007) Standard guide for conducting acute toxicity tests with fishes, macroinvertebrates, and amphibians. American society for test and materials, Philadelphia, pp 729–796
Barron MG, Raimondo S, Russom C, Vivian DN, Yee SH (2008) Accuracy of chronic aquatic toxicity estimates determined from acute toxicity data and two time–response models. Environ Toxicol Chem 27:2196–2205. doi:10.1897/08-004.1
Bodar C, de Bruijn J, Vermeire T, van der Zandt P (2002) Trends in risk assessment of chemicals in the European Union. Hum Ecol Risk Assess 8:1825–1843. doi:10.1080/20028091056881
Bradury SP, Feijtel TC, van Leeuwen CJ (2004) Meeting the scientific needs of ecological risk assessment in a regulatory context. Environ Sci Technol 38:463A–470A. doi:10.1021/es040675s
Buckler DR, Mayer FL, Ellersieck MR, Asfaw A (2003) Evaluation of minimum data requirements for acute toxicity value extrapolation. US Environmental Protection Agency Report. No. EPA/600/R-03/104, Washington
Buckler DR, Mayer FL, Ellersieck MR, Asfaw A (2005) Acute toxicity value extrapolation with fish and aquatic invertebrates. Arch Environ Contam Toxicol 49:546–558. doi:10.1007/s00244-004-0151-8
De Zwart D (2002) Observed regularities in species sensitivity distributions for aquatic species. In: Posthuma L, Suter GW, Traas TP (eds) Species sensitivity distributions in ecotoxicology. Lewis, Boca Raton, pp 133–154
Dyer SD, Versteeg DJ, Belanger SE, Chaney JG, Mayer FL (2006) Interspecies correlation estimates predict protective environmental concentrations. Environ Sci Technol 40:3102–3111. doi:10.1021/es051738p
Dyer SD, Versteeg DJ, Belanger SE, Chaney JG, Raimondo S, Barron MG (2008) Comparison of species sensitivity distributions derived from interspecies correlation models to distributions used to derive water quality criteria. Environ Sci Technol 42:3076–3083. doi:10.1021/es702302e
Fairbrother A (2008) Risk management safety factor. In: Jørgensen SE, Fath BD (eds) Encyclopedia of ecology: ecotoxicology, vol 4. Elsevier, Amsterdam, pp 3062–3068
Fisher SW, Dabrowska H, Waller DL, Babcock-Jackson L, Zhang X (1994) Sensitivity of zebra mussel (Dreissena polymorpha) life stages to candidate molluscicides. J Shellfish Res 13:373–377
Froese R, Pauly D (2008) FishBase. World Wide Web electronic publication. www.fishbase.org, version (06/2008). Accessed 10 Oct 2008
Gaikowski MP, Hamilton SJ, Buhl KJ, McDonald SF, Summers CH (1996) Acute toxicity of firefighting chemical formulations to four life stages of fathead minnow. Ecotoxicol Environ Saf 34:252–263. doi:10.1006/eesa.1996.0070
Gerhardt A (1992) Acute toxicity of Cd in stream invertebrates in relation to pH and test design. Hydrobiologia 239:93–100. doi:10.1007/BF00012575
Hedtke SF, West CW, Allen KN, Norberg-King TJ, Mount DI (1986) Toxicity of pentachlorophenol to aquatic organisms under naturally varying and controlled environmental conditions. Environ Toxicol Chem 5:531–542. doi:10.1897/1552-8618(1986)5[531:TOPTAO]2.0.CO;2
Hutchinson TH, Solbe J, Kloepper-Sams PJ (1998) Analysis of the Ecetoc aquatic toxicity (EAT) database III–Comparative toxicity of chemical substances to different life stages of aquatic organisms. Chemosphere 36:129–142. doi:10.1016/S0045-6535(97)10025-X
Kim Y, Jung J, Oh S, Choi K (2008) Aquatic toxicity of cartap and cypermethrin to different life stages of Daphnia magna and Oryzia latipes. J Environ Sci Health B 43:56–64. doi:10.1080/03601230701735029
Macek KJ, Sleight BHIII (1977) Utility of toxicity tests with embryos and fry of fish in evaluating hazards associated with chronic toxicity of chemicals to fishes. In: Mayer FL, Hamelink JL (eds) Aquatic toxicology and hazard evaluation, ASTM STP 634. American Society for Testing and Materials, Philadelphia, pp 137–146
Mayer FL, Ellersieck MR (1986) Manual of acute toxicity: interpretation and data base for 410 chemicals and 66 species of freshwater animals. Publication 160. US Fish and Wildlife Service Resource, Washington
Mayer FL, Marking LL, Bills TD, Howe GE (1994) Physicochemical factors affecting toxicity in freshwater: hardness, pH, and temperature. In: Hamelink JL, Bergman HL, Kimberle RA, Landrum PF (eds) A mechanistic understanding of bioavailability. Lewis, Boca Raton, pp 5–22
Mayer FL, Ellersieck MR, Krause GF, Sun K, Lee G, Buckler DR (2002) Time–concentration effect models in predicting chronic toxicity from acute toxicity data. In: Crane M, Newman MC, Chapman PF, Fenlon J (eds) Risk assessment with time to event models. Lewis, Boca Raton, pp 39–67
McKim JM (1985) Early life stage toxicity tests. In: Rand GM, Petrocelli SR (eds) Fundamentals of aquatic toxicology. Hemisphere, Washington, pp 58–95
Medina M, Carata C, Telfer T, Baird DJ (2002) Age- and sex-related variation in sensitivity to the pyrethriod cypermethrin in the marine copepod Acartia tonsa Dana. Arch Environ Contam Toxicol 42:17–22. doi:10.1007/s002440010286
Moles A (1998) Sensitivity of ten aquatic species to long-term crude oil exposure. Bull Environ Contam Toxicol 61:102–107. doi:10.1007/s001289900735
NAS (2007) Toxicity testing in the 21st Century: a vision and a strategy. Final report. National Academies Press, Washington
Newman MC, Ownby DR, Mézin LCA, Powell DC, Christensen TRL, Lerberg SB, Anderson BA (2000) Applying species-sensitivity distributions in ecological risk assessment: assumptions of distribution type and sufficient numbers of species. Environ Toxicol Chem 19:508–515. doi:10.1897/1551-5028(2000)019<0508:ASSDIE>2.3.CO;2
OECD (1992) OECD guideline for testing of chemicals. Fish, acute toxicity test. OECD TG 203. Organization for Economic Co-operation and Development, Paris
Raimondo S, Vivian D, Barron MG (2007a). Web-based interspecies correlation estimation (Web-ICE) for acute toxicity: user manual. Version 1.1. EPA/600/R-07-071. Gulf Breeze. pp 26. http://www.epa.gov/ceampubl/fchain/webice/index.htm. Accessed Sept 2008
Raimondo S, Mineau P, Barron MG (2007b) Estimation of chemical toxicity to wildlife species using interspecies correlation models. Environ Sci Technol 41(16):5888–5894. doi:10.1021/es070359o
Raimondo S, Montague BJ, Barron MG (2007c) Determinants of variability in acute-to-chronic toxicity ratios (ACRs) in aquatic invertebrates and fish. Environ Toxicol Chem 26:2019–2023. doi:10.1897/07-069R.1
Raimondo S, Vivian DN, Delos C, Barron MG (2008) Protectiveness of Species sensitivity distribution hazard concentrations for acute toxicity used in endangered species risk assessment. Environ Toxicol Chem 27:2599–2607. doi:10.1897/08-157.1
Sokal RR, Rohlf FJ (1998) Biometry. W.H. Freeman and Company, New York
Sprague JB (1973) The ABC’s of pollutant bioassay using fish. ASTM special technical publication. American Society for Testing and Materials, Philadelphia, pp 6–30
USEPA (1986) Quality criteria for water. EPA 440/5-86-001. Washington
USEPA (1996a) 1995 Updates: water quality criteria documents for the protection of aquatic life in ambient water. EPA-820-B-96-001. Final Report. Washington
USEPA (1996b) Ecological effects test guidelines. OPPTS 850.1075 Fish acute toxicity test, freshwater and marine. Environmental Protection Agency. EPA 712-C-96-118. Washington
USEPA (2002) National recommended water quality criteria: 2002. EPA-822-R-02-047. Final Report. Washington
USEPA (2007) ECOTOX User Guide: ECOTOXicology Database System. Version 4.0. Available http:/www.epa.gov/ecotox/. Accessed May 2007
Versteeg DJ, Belanger SE, Carr GJ (1999) Understanding single species and model ecosystem sensitivity: data-base comparison. Environ Toxicol Chem 18:1329–1346. doi:10.1897/1551-5028(1999)018<1329:USSAME>2.3.CO;2
Wang N, Ingersoll CG, Hardesty DK, Ivey CD, Kunz JL, May TW, Dwyer FJ, Roberts AD, Augspurger T, Kane CM, Neves RJ, Barnhart C (2007) Acute toxicity of copper, ammonia, and chlorine to glochidia and juveniles of freshwater mussels (Unionidae). Environ Toxicol Chem 26:2036–2047. doi:10.1897/06-523R.1
Wang B, Yu G, Huang J, Hu H (2008) Development of species sensitivity distributions and estimation of HC5 of organochlorine pesticides with five statistical approaches. Ecotoxicology 17:716–724. doi:10.1007/s10646-008-0220-2
Acknowledgments
Sorci Soriano, Marion Marchetto, and Sarah Kell provided invaluable assistance with database quality assurance. Sonya Doten assisted with collection of technical materials. Chuck Stephan reviewed an earlier version of this manuscript. The information in this document has been funded by the US Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. This is contribution number 1350 from the Gulf Ecology Division.
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Raimondo, S., Vivian, D.N. & Barron, M.G. Standardizing acute toxicity data for use in ecotoxicology models: influence of test type, life stage, and concentration reporting. Ecotoxicology 18, 918–928 (2009). https://doi.org/10.1007/s10646-009-0353-y
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DOI: https://doi.org/10.1007/s10646-009-0353-y