Investigational New Drugs

, Volume 34, Issue 5, pp 643–649 | Cite as

The renal effects of ALK inhibitors

  • Hassan IzzedineEmail author
  • Rania Kheder El-Fekih
  • Mark A. Perazella


Anaplastic lymphoma kinase 1 (ALK-1) is a member of the insulin receptor tyrosine kinase family. In clinical practice, three small molecule inhibitors of ALK-1 are used, namely crizotinib, ceritinib and alectinib. Several more agents are in active pre-clinical and clinical studies. Crizotinib is approved for the treatment of advanced ALK-positive non-small cell lung cancer (NSCLC). According to the package insert and published literature, treatment with crizotinib appears to be associated with kidney failure as well as an increased risk for the development and progression of renal cysts. In addition, this agent is associated with development of peripheral edema and rare electrolyte disorders. This review focuses on the adverse renal effects of Crizotinib in clinical practice.


Anaplastic lymphoma kinase ALK-1 Crizotinib Serum creatinine Cyst Onco-nephrology 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Hassan Izzedine
    • 1
    Email author
  • Rania Kheder El-Fekih
    • 2
  • Mark A. Perazella
    • 3
  1. 1.Department of NephrologyMonceau Park International Clinic ParisParisFrance
  2. 2.Department of NephrologyLa Rabta HospitalTunisTunisia
  3. 3.Department of NephrologyYale University School of MedicineNew HavenUSA

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