Investigational New Drugs

, Volume 34, Issue 5, pp 650–653 | Cite as

Intravitreal vascular endothelial growth factor (VEGF) inhibitor injection in unrecognised early pregnancy

  • Farzan Kianersi
  • Heshmatollah Ghanbari
  • Zahra Naderi Beni
  • Afsaneh Naderi BeniEmail author


The use of intravitreal vascular endothelial growth factor (VEGF) inhibitor medications has widened considerably to include indications affecting females of reproductive age. Our patient was inadvertently exposed to bevacizumab within the first trimester when placental growth and fetal organogenesis take place and patient suffered pregnancy loss. There is insufficient information to suggest that such use is safe, nor is there definitive evidence to suggest that it causes harm. We advise that ophthalmologists discuss pregnancy with women of childbearing age undergoing intraocular anti-VEGF injections and in pregnant woman counselling is needed to explain the potential risks and benefits.


Intravitreal vascular endothelial growth factor Pregnancy Complication 


Compliance with ethical standards

Conflict of interest

Authors do not have any financial interest in the subject matter of this article.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Farzan Kianersi
    • 1
  • Heshmatollah Ghanbari
    • 1
  • Zahra Naderi Beni
    • 2
  • Afsaneh Naderi Beni
    • 3
    Email author
  1. 1.Department of OphthalmologyIsfahan University of Medical SciencesIsfahanIran
  2. 2.Department of Oncology and RadiotherapyIsfahan University of Medical SciencesIsfahanIran
  3. 3.Department of OphthalmologyShahrekord University of Medical SciencesShahrekordIran

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