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Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562

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Summary

Quorum sensing is defined as the ability of microorganisms to sense their population density via the release of signaling molecules called autoinducers (AIs). Various types of AI analogs were prepared and their antitumor properties against chronic myeloid leukemia (CML) K562 cells were investigated. Two AI analogs induced progressive apoptosis with JNK activation and p21 induction. In addition, this induction of apoptosis is not related to bcr-abl kinase, which sustains CML proliferation. However, the progression of　apoptosis was not inhibited by a caspase family inhibitor. These results suggested that AI analogs could induce caspase-independent apoptosis in CML K562.

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Acknowledgments

This work was received the support from a Grant for Hirosaki University Institutional Research (2008–2010).

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Authors and Affiliations

  1. Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori, 036-8564, Japan

    Masaharu Hazawa, Michiko Kudo, Toshihiro Iwata, Kazuki Saito & Ikuo Kashiwakura

  2. Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, Tottori, 680-8533, Japan

    Kenji Takahashi

  3. Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro, Tokyo, 153-8904, Japan

    Jun Igarashi & Hiroaki Suga

Authors
  1. Masaharu Hazawa
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  2. Michiko Kudo
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  3. Toshihiro Iwata
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  4. Kazuki Saito
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  5. Kenji Takahashi
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  8. Ikuo Kashiwakura
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Correspondence to Ikuo Kashiwakura.

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Hazawa, M., Kudo, M., Iwata, T. et al. Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562. Invest New Drugs 30, 862–869 (2012). https://doi.org/10.1007/s10637-010-9623-z

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  • DOI: https://doi.org/10.1007/s10637-010-9623-z

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