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Investigational New Drugs

, 27:586 | Cite as

Cyclin-dependent kinase inhibitors as potential targeted anticancer agents

  • Ivan Diaz-Padilla
  • Lillian L. Siu
  • Ignacio DuranEmail author
Review

Summary

Cyclin-dependent kinases (CDKs) are core components of the cell cycle machinery that govern the transition between phases during cell cycle progression. Genes involved in cell cycle are frequently mutated in human cancer and deregulated CDK activity represents a hallmark of malignancy. This knowledge provides a rationale for regarding CDKs and their associated molecules as potential targets for new drug development in anticancer research. The present article will review the most relevant CDK inhibitors with emphasis on the newer molecules in clinical development and the biological rationale of this therapeutic approach.

Keywords

Cell-cycle Cyclin-dependent kinase Flavopiridol Targeted therapies CDK inhibitors 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ivan Diaz-Padilla
    • 1
  • Lillian L. Siu
    • 2
  • Ignacio Duran
    • 1
    Email author
  1. 1.Medical Oncology DepartmentCentro Integral Oncologico “Clara Campal”MadridSpain
  2. 2.Princess Margaret HospitalTorontoCanada

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