Investigational New Drugs

, 27:583 | Cite as

Wound healing delay after central venous access following DCF/VEGF-trap therapy

  • Charles FertéEmail author
  • Christophe Massard
  • Christian Moldovan
  • Eric Desruennes
  • Yohann Loriot
  • Jean-Charles Soria


Hypertension, proteinuria, thromboembolic or bleeding events are well-recognized complications occurring while targeting VEGF pathway. Wound healing dysfunctions have also been described in patients undergoing major surgery. For the first time, we report wound healing delay after central venous access following DCF-VEGF-Trap. VEGF-Trap may affect both angiogenesis and reepithelialization which are necessary to the normal repair process.


VEGF-Trap Wound healing Central venous access 


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Charles Ferté
    • 1
    Email author
  • Christophe Massard
    • 1
  • Christian Moldovan
    • 1
  • Eric Desruennes
    • 2
  • Yohann Loriot
    • 1
  • Jean-Charles Soria
    • 1
  1. 1.Department of MedicineInstitut Gustave Roussy, Phase I unit (SITEP)VillejuifFrance
  2. 2.Department of AnaesthesiologyInstitut Gustave RoussyVillejuifFrance

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