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Investigational New Drugs

, Volume 26, Issue 6, pp 567–572 | Cite as

Effect of oral administration of kefir on serum proinflammatory cytokines on 5-FU induced oral mucositis in patients with colorectal cancer

  • E. Topuz
  • D. DerinEmail author
  • G. Can
  • E. Kürklü
  • S. Çınar
  • F. Aykan
  • A. Çevikbaş
  • R. Dişçi
  • Z. Durna
  • B. Şakar
  • S. Saglam
  • H. Tanyeri
  • G. Deniz
  • Ü. Gürer
  • F. Taş
  • N. Guney
  • A. Aydıner
PHASE II STUDIES

Summary

In order to investigate the effect of kefir consumption on mucositis induced by 5-FU based chemotherapy (CT), we monitored the systemic immune response by measurement of the serum proinflammatory cytokine levels and we evaluated the anti-microbial effect of kefir with an agar diffusion method. Forty patients with colorectal cancer were included in this randomized prospective study. On the first 5 days of each CT cycle, the study group received oral lavage with kefir and then swallowed 250 ml of kefir while control group received oral lavage with 0.09% NaCl twice a day. Before and after every cycle of CT, the oral mucosa was assessed. Serum proinflammatory cytokine levels were evaluated before the initiation and after the third and the sixth cycle. Kefir was administered in 99 out of 205 courses. Mucositis developed in 27.3% of the courses given with kefir administration and in 21.7% of the courses given with 0.9% NaCl oral rinses. The difference between the two groups was not statistically significant (p > 0.05). When we compared the serum proinflammatory cytokine levels of the two groups at the baseline and following the third and the sixth cycles, we again found no statistically significant difference (p > 0.05). Kefir consumption at the mentioned doses made no statistically significant effect on serum proinflammatory cytokine levels and on the incidence of mucositis development in cancer patients. Under in vitro conditions, kefir inhibits only Staphylococcus epidermidis.

Keywords

Serum proinflammatory cytokines Mucositis Kefir 

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • E. Topuz
    • 1
  • D. Derin
    • 2
    Email author
  • G. Can
    • 3
  • E. Kürklü
    • 4
  • S. Çınar
    • 5
  • F. Aykan
    • 1
  • A. Çevikbaş
    • 6
  • R. Dişçi
    • 7
  • Z. Durna
    • 3
  • B. Şakar
    • 1
  • S. Saglam
    • 1
  • H. Tanyeri
    • 4
  • G. Deniz
    • 5
  • Ü. Gürer
    • 6
  • F. Taş
    • 1
  • N. Guney
    • 1
  • A. Aydıner
    • 1
  1. 1.Onkoloji Enstitüsüİstanbul ÜniversitesiIstanbulTurkey
  2. 2.Medikal Onkoloji KliniğiKayseri Eğitim ve Araştırma HastanesiKayseriTurkey
  3. 3.Florence Nightingale Hemşirelik Yüksekokuluİstanbul ÜniversitesiIstanbulTurkey
  4. 4.Diş Hekimliği Fakültesi Ağız, Diş, Çene Hastalıkları Bilim Dalıİstanbul ÜniversitesiIstanbulTurkey
  5. 5.Deneysel Tıp Araştırma Enstitüsü İmmünolojiİstanbul ÜniversitesiIstanbulTurkey
  6. 6.Farmasötik MikrobiyolojiMarmara ÜniversitesiIstanbulTurkey
  7. 7.İstanbul Tıp FakültesiDahili Tıp Bilimleri Halk SağlığıIstanbulTurkey

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