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Rhinitis and epistaxis in patients treated by anti-angiogenic therapy

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Summary

Anti-angiogenic therapies have a particular drug-related toxicity profile including hypertension, thrombosis, haemorrhages, and proteinuria. Moreover, patients treated by angiogenesis inhibitors present nasal symptoms including symptomatic rhinitis and epistaxis. For the first time, a new entity of “atrophic rhinitis” induced by angiogenesis inhibitors is described and revealed that angiogenesis inhibitors alter the differentiation of nasal epithelium. VEGF may act on epithelial cell proliferation and differentiation in nasal epithelium.

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Authors and Affiliations

  1. Service d’ORL et de Chirurgie Cervico-Faciale, Hôpitaux H. Mondor (Assistance Publique Hôpitaux de Paris) et Centre Hospitalier Intercommunal de Créteil, Paris, France

    V. Prulière-Escabasse & A. Coste

  2. Service de Génétique et Embryologie Médicales Hôpital Armand Trousseau (Assistance Publique Hôpitaux de Paris) et U654, Paris, France

    E. Escudier

  3. Department of Medicine, Phase I Unit, Institut Gustave Roussy, Villejuif, 94800, France

    R. Balheda, J. C. Soria & C. Massard

Authors
  1. V. Prulière-Escabasse
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  2. E. Escudier
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  3. R. Balheda
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  4. J. C. Soria
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  5. A. Coste
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  6. C. Massard
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Corresponding author

Correspondence to C. Massard.

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Prulière-Escabasse, V., Escudier, E., Balheda, R. et al. Rhinitis and epistaxis in patients treated by anti-angiogenic therapy. Invest New Drugs 27, 285–286 (2009). https://doi.org/10.1007/s10637-008-9168-6

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  • DOI: https://doi.org/10.1007/s10637-008-9168-6

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