Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer

  • Manon Buijs
  • Josephina A. Vossen
  • Jean-Francois H. GeschwindEmail author
  • Takayoshi Ishimori
  • James M. Engles
  • Obele Acha-Ngwodo
  • Richard L. Wahl
  • Mustafa Vali


Purpose: To evaluate the anti-glycolytic effects of 3-BrPA on rats bearing RMT mammary tumors, by determining FDG uptake after intravenous administration of the therapeutic dose. Materials and Methods: Sixteen rats bearing RMT tumors were treated either with 15 mM 3-BrPA in 2.5 ml of PBS or with 2.5 ml of PBS. After treatment, all rats received FDG and were sacrificed 1 h later. Results: 3-BrPA treatment significantly decreased FDG uptake in tumors by 77% (p = 0.002). FDG uptake did not significantly decrease in normal tissues after treatment. Conclusion: Our study showed that 3-BrPA exhibits a strong anti-glycolytic effect on RMT cells implanted in rats.


Breast cancer 3-Bromopyruvate FDG RMT Animal model 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Manon Buijs
    • 1
  • Josephina A. Vossen
    • 1
  • Jean-Francois H. Geschwind
    • 1
    Email author
  • Takayoshi Ishimori
    • 1
  • James M. Engles
    • 1
  • Obele Acha-Ngwodo
    • 1
  • Richard L. Wahl
    • 1
  • Mustafa Vali
    • 1
  1. 1.Russell H. Morgan Department of Radiology, and Radiological SciencesDivision of Vascular and Interventional RadiologyBaltimoreUSA

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