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Investigational New Drugs

, Volume 25, Issue 3, pp 277–278 | Cite as

Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatin therapy

  • C. A. SteinEmail author
  • Sanjay Goel
  • Reza Ghavamian
Short Report

Itakura et al. [1] have recently reported a case of a 73-year old man with hormone refractory prostate cancer who experienced rhabdomyolysis after treatment with the azole drug ketoconazole plus hydrocortisone while concurrently receiving simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Ketoconazole is a potent inhibitor of the enzyme cytochrome P450 [CYP] 3A4; several statins, including simvastatin and lovastatin, interact with this hepatic microsomal enzyme, which is responsible in significant part for statin clearance [2]. Since the number of men treated with the combination of ketoconazole and hydrocortisone for prostate malignancy is increasing, Itakura et al. [1] predicted that rhabdomyolysis will become more prevalent. However, it is not clear if the statin/ketoconazole drug interaction leading to rhabdomyolysis in men with prostate cancer is a general property of the statins as a drug class, or is an event relatively restricted to simvastatin [3]. For...

Keywords

Ketoconazole Hepatitis Rhabdomyolysis Lovastatin Prostatic neoplasms 

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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  1. 1.Albert Einstein College of Medicine and Montefiore Cancer CenterBronxUSA
  2. 2.Department of Oncology, Montefiore Medical CenterBronxUSA

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