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Impact of taurolidin and octreotide on liver metastasis and lipid peroxidation after laparoscopy in chemical induced ductal pancreatic cancer

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Summary

Background: There is controversial discussion whether metastasis initiated by laparoscopy with carbon dioxide might be prevented by instillation of taurolidin or radical scavengers like the somatostatin analogue Octreotide. Therefore we evaluated the effects of laparoscopic lavage with taurolidin and Octreotide on liver metastasis after staging laparoscopy in ductal pancreatic cancer. Methods: In 60 Syrian hamsters pancreatic adenocarcinoma was induced by weekly subcutanous injection of 10 mg N-nitrosobis-2-oxopropylamin/kg body weight for 10 weeks. In the 16th week laparoscopic staging biopsy by use of carbon dioxide was performed. Finally animals underwent abdominal irrigation with saline (gr.1, n = 20), taurolidin (0.5%) (gr.2, n = 20) or Octreotide (gr.3, n = 20). In week 25 animals were sacrificed, pancreas and liver were analysed. Results: Size of pancreatic carcinomas was decreased in the taurolidin gr. compared to the other two groups. Furthermore the number of liver metastasis per animal was reduced after lavage with taurolidin (2 ± 2) and Octreotide (2.5 ± 2) compared to saline irrigation (4 ± 4) (p < 0.05). Additionally the incidence of port site metastases was significantly reduced in the taurolidin group. Activity of antioxidative enzyme superoxide dismutase (SOD) was increased while concentration of products of lipidperoxidation was decreased in non-metastatic liver after taurolidin irrigation compared to saline or Octreotide irrigation. Conclusions: Taurolidin irrigation during laparoscopy might be a new concept to reduce the number of liver metastasis and port site metastases in pancreatic cancer.

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Authors and Affiliations

  1. Clinic of General, Visceral, Vascular and Thoracic Surgery, Humboldt-University, Schumannstr. 2/21, 10117, Berlin, Germany

    Maik Kilian, Jan Ilga Gregor, Chris Braumann & Christoph Andreas Jacobi

  2. Clinic of Hepatology, Gastroenterology and Endocrinology, Humboldt-University, Schumannstr. 2/21, 10117, Berlin, Germany

    Ina Heukamp

  3. Institute of Pathology, Humboldt-University, Schumannstr. 2/21, 10117, Berlin, Germany

    Hans Guski

  4. Clinic of Internal Medicine I, Charité Campus Mitte, Humboldt-University, Schumannstr. 2/21, 10117, Berlin, Germany

    Ingolf Schimke

  5. Clinic of Surgery and Center of Minimal-invasive Surgery, Huyssens-Stiftun/Knappschafts-GmbH, Kliniken Essen-Mitte, Henricistraße 92, 45136, Essen, Germany

    Martin Karl Walz & Frank Axel Wenger (Priv.-Doz. Dr. med.)

  6. Clinic of Surgery and Center of Minimal-Invasive Surgery, Huyssens-Stiftun/Knappschafts-GmbH, Kliniken Essen-mitte, Henricistraße 92, 45136, Germany

    Frank Axel Wenger (Priv.-Doz. Dr. med.)

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  1. Maik Kilian
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  2. Jan Ilga Gregor
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  3. Ina Heukamp
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  4. Chris Braumann
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  5. Hans Guski
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  6. Ingolf Schimke
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  8. Christoph Andreas Jacobi
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  9. Frank Axel Wenger
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Correspondence to Frank Axel Wenger.

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Kilian, M., Gregor, J.I., Heukamp, I. et al. Impact of taurolidin and octreotide on liver metastasis and lipid peroxidation after laparoscopy in chemical induced ductal pancreatic cancer. Invest New Drugs 23, 157–164 (2005). https://doi.org/10.1007/s10637-005-5861-x

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  • DOI: https://doi.org/10.1007/s10637-005-5861-x

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