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Comparison between multifocal ERG and C-Scan SD-OCT (“en face” OCT) in patients with a suspicion of antimalarial retinal toxicity: preliminary results

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Abstract

Purpose

Pericentral visual field changes and disruption of the ellipsoid layer on spectral domain optical coherence tomography (SD-OCT) are the main features of antimalarial retinal toxicity. C-Scan OCT or “en face” enables a topographic frontal view of the changes observed within the different retinal layers in particular the ellipsoid layer. The aim of this prospective study was to compare multifocal ERG (mfERG) responses with the results of C-Scan OCT (“en face” OCT) in patients with abnormal visual field and to analyze relationships between the structural and functional abnormalities.

Methods

In 354 consecutive patients screened for antimalarial toxicity between January 1, 2014 and December 31, 2016, central visual field, mfERG recording, C-Scan OCT and short-wavelength fundus autofluorescent imaging were performed.

Results

Among the 17/354 patients with abnormal central visual field results, all presented with abnormalities on the mfERG at least in one eye. In 16/33 eyes, there was a good concordance between focal loss of the mfERG response and the disruption of the ellipsoid layer on C-Scan OCT. In one eye with characteristic changes in the ellipsoid layer on the C-Scan OCT, the mfERG was normal, whereas in three eyes the mfERG was abnormal in eyes with a normal C-Scan OCT.

Conclusions

The contribution of the C-Scan OCT changes remains difficult to establish as there is no strict concordance with the local ERG responses. Although C-Scan OCT technology provides a new approach in analyzing focal abnormalities in the photoreceptor–retinal pigment epithelium interface, the sensitivity of this method compared with mfERG and other tests (central visual field, B-Scan OCT) needs to be evaluated. This study is still ongoing on a larger cohort.

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Authors and Affiliations

  1. Ophthalmology Department, Reims University Hospital, Reims, France

    Carl Arndt, Mathieu Costantini, Mickael Afriat & Alain Ducasse

  2. Ophthalmology Department, Grenoble-Alpes University Hospital, Grenoble-Alpes University, Grenoble, France

    Christophe Chiquet & Sylvie Berthemy

  3. Clinical Research Department, Rothschild Foundation, Paris, France

    Vivien Vasseur & Martine Mauget-Faÿsse

Authors
  1. Carl Arndt
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  2. Mathieu Costantini
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  3. Christophe Chiquet
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  4. Mickael Afriat
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  5. Sylvie Berthemy
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  6. Vivien Vasseur
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  7. Alain Ducasse
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  8. Martine Mauget-Faÿsse
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Corresponding author

Correspondence to Carl Arndt.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakera’s bureaus; membership; employment; consultancies; stock ownership; or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Arndt, C., Costantini, M., Chiquet, C. et al. Comparison between multifocal ERG and C-Scan SD-OCT (“en face” OCT) in patients with a suspicion of antimalarial retinal toxicity: preliminary results. Doc Ophthalmol 136, 97–111 (2018). https://doi.org/10.1007/s10633-018-9625-2

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  • DOI: https://doi.org/10.1007/s10633-018-9625-2

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