Abstracts: XLVII ISCEV International Symposium
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Invited Lecture 1: Injecting the eye: neurosensory retinal and intravitreal drugs for degenerative retinal diseases
Professor Edoardo Midena
Department of Ophthalmology, University of Padova, Padova, Italy & Fondazione GB Bietti per l’Oftalmologia, IRCCS, Roma, Italy
The treatment of major degenerative retinal diseases, namely age-related macular degeneration and diabetic retinopathy, is tending towards a pharmacologic approach compared to the previous physical therapy. Systemic treatments have demonstrated more complications than benefits, and so there is an increasing and enthusiastic trend toward direct local (intraocular) therapy. A number of different drugs are currently used or under investigation. Most of these drugs are selective or unselective vascular endothelial growth factor (VEGF) antagonists, because VEGF is considered a key factor in the pathogenesis of intraocular neovascularisation, both retinal and choroidal. VEGF properties also favour hyperpermeability of retinal...