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Transitions of multifocal electroretinography following combined intravitreal bevacizumab and photodynamic therapy for polypoidal choroidal vasculopathy

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Abstract

To investigate the changes in the multifocal electroretinography (ERG) after combined intravitreal bevacizumab and photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) patients. Thirteen eyes of 13 patients were included in the study. The latencies and average response densities of all the six ring retinal regions were measured and compared before treatment and 1, 3, and 6 months after treatment. The latencies of the N1 and P1 waves in all the six rings remained unchanged compared with pre-treatment. Significant increase of average response densities of both P1 in ring 1 (P = 0.023) and N1, P1 in ring 2 (P = 0.028 and 0.046, respectively) were detected at 3 months post-treatment. The increase of P1 amplitude densities in ring 1 (P = 0.015) and N1, P1 amplitude densities in ring 2 (P = 0.031 and 0.034, respectively) were also significant at 6 months post-treatment. In conclusion, combined intravitreal bevacizumab and PDT is associated with an increase of multifocal ERG centrally in PCV patients.

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Acknowledgments

This study was supported by the National Basic Research Program of China (grant no. 2007CB512206).

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Authors and Affiliations

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 Xianlie Road, Guangzhou, 510060, China

    Chengguo Zuo, Feng Wen, Jiaqing Li, Yan Liu & Meng Li

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  1. Chengguo Zuo
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  2. Feng Wen
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  3. Jiaqing Li
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  4. Yan Liu
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  5. Meng Li
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Correspondence to Feng Wen.

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The study conformed to the provisions of the Declaration of Helsinki and informed consent was obtained from all the patients. The authors indicate no conflict of interest. The authors have full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis as well as the decision to submit for publication.

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Zuo, C., Wen, F., Li, J. et al. Transitions of multifocal electroretinography following combined intravitreal bevacizumab and photodynamic therapy for polypoidal choroidal vasculopathy. Doc Ophthalmol 119, 29–36 (2009). https://doi.org/10.1007/s10633-009-9166-9

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  • DOI: https://doi.org/10.1007/s10633-009-9166-9

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