Imaging and the perspective of clinical electrophysiology
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Clinical electrophysiology allows a detailed analysis of retinal function in various disorders. When for decades the morphological examination of the retina was limited to ophthalmoscopy and fluorescein angiography, electrophysiological techniques allowed detection of retinal abnormalities in morphologically “normal” retina: e.g. cone dystrophies with the full-field ERG, early stages of macular dystrophies with the pattern ERG (PERG) or multifocal ERG (mfERG), early stages of chloroquine retinopathy with the mfERG, non-manifesting carriers of Best disease with the EOG or retinal ganglion cell damage in autosomal dominant optic atrophy with the VEP.
In recent years, new techniques for the evaluation of retinal morphology have been introduced in clinical practice. Optical coherence tomography (OCT) within the last 15 years has evolved from frequency domain techniques to the fourth generation with spectral domain techniques, and further development with even higher resolution and...
KeywordsClinical electrophysiology Retinal imaging
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