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Functional study in NSE-Hu-Bcl-2 transgenic mice: a model for retinal diseases starting in Müller cells

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Abstract

In NSE-Hu-Bcl-2 transgenic mice, line 71, retina undergoes early postnatal degeneration linked to the prior death of Müller cells. The purpose of this study was to complete the characterization of this retinal dysfunction by using electroretinographic (ERG) recordings in both scotopic and photopic conditions. Here, we showed that both rod and cone systems were profoundly affected in NSE-Hu-Bcl-2 transgenic mice as soon as 15 postnatal days in accordance with histological study performed previously.

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Abbreviations

cds/m2 :

Candelas*second/m2

ERG:

Electroretinography

IT:

Implicit time

MCs:

Müller glial cells

NSE-Hu-Bcl-2 mouse:

Mouse over-expressing the human Bcl-2 under the control of neuron-specific enolase promotor

OPs:

Oscillatory potentials

PN:

Postnatal day

WT:

Wild-type

tg:

Transgenic

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Aknowledgements

This work was supported by the Provisu Foundation, Schmidheiny Foundation, De Reuter Foundation and Novartis Foundation grants to L.E-C.

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Authors and Affiliations

  1. Department of Basic Neuroscience, Medical School, University of Geneva, Geneva, Switzerland

    Cécile Péant & Lorenza Eder-Colli

  2. Laboratory of Cell Biology, Ophthalmology Clinic, Geneva University Hospital, Rue Alcide Jentzer 22, 1211, Geneva 14, Switzerland

    André Dosso & Florence Chiodini

Authors
  1. Cécile Péant
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  2. André Dosso
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  3. Lorenza Eder-Colli
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  4. Florence Chiodini
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Correspondence to Florence Chiodini.

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Péant, C., Dosso, A., Eder-Colli, L. et al. Functional study in NSE-Hu-Bcl-2 transgenic mice: a model for retinal diseases starting in Müller cells. Doc Ophthalmol 115, 203–209 (2007). https://doi.org/10.1007/s10633-007-9077-6

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  • DOI: https://doi.org/10.1007/s10633-007-9077-6

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