Functional study in NSE-Hu-Bcl-2 transgenic mice: a model for retinal diseases starting in Müller cells
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In NSE-Hu-Bcl-2 transgenic mice, line 71, retina undergoes early postnatal degeneration linked to the prior death of Müller cells. The purpose of this study was to complete the characterization of this retinal dysfunction by using electroretinographic (ERG) recordings in both scotopic and photopic conditions. Here, we showed that both rod and cone systems were profoundly affected in NSE-Hu-Bcl-2 transgenic mice as soon as 15 postnatal days in accordance with histological study performed previously.
KeywordsBcl-2 over-expression Electroretinogram Müller cells Photoreceptors Retinal degeneration
Müller glial cells
- NSE-Hu-Bcl-2 mouse
Mouse over-expressing the human Bcl-2 under the control of neuron-specific enolase promotor
This work was supported by the Provisu Foundation, Schmidheiny Foundation, De Reuter Foundation and Novartis Foundation grants to L.E-C.
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