Documenta Ophthalmologica

, Volume 115, Issue 3, pp 203–209 | Cite as

Functional study in NSE-Hu-Bcl-2 transgenic mice: a model for retinal diseases starting in Müller cells

  • Cécile Péant
  • André Dosso
  • Lorenza Eder-Colli
  • Florence Chiodini
Original Research Article


In NSE-Hu-Bcl-2 transgenic mice, line 71, retina undergoes early postnatal degeneration linked to the prior death of Müller cells. The purpose of this study was to complete the characterization of this retinal dysfunction by using electroretinographic (ERG) recordings in both scotopic and photopic conditions. Here, we showed that both rod and cone systems were profoundly affected in NSE-Hu-Bcl-2 transgenic mice as soon as 15 postnatal days in accordance with histological study performed previously.


Bcl-2 over-expression Electroretinogram Müller cells Photoreceptors Retinal degeneration 







Implicit time


Müller glial cells

NSE-Hu-Bcl-2 mouse

Mouse over-expressing the human Bcl-2 under the control of neuron-specific enolase promotor


Oscillatory potentials


Postnatal day







This work was supported by the Provisu Foundation, Schmidheiny Foundation, De Reuter Foundation and Novartis Foundation grants to L.E-C.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Cécile Péant
    • 1
  • André Dosso
    • 2
  • Lorenza Eder-Colli
    • 1
  • Florence Chiodini
    • 2
  1. 1.Department of Basic Neuroscience, Medical SchoolUniversity of GenevaGenevaSwitzerland
  2. 2.Laboratory of Cell Biology, Ophthalmology ClinicGeneva University HospitalGeneva 14Switzerland

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