Cure My Virus: Hematemesis and Melena in a Transplant Recipient

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2

References

  1. 1.

    Zuhair M et al. Estimation of the worldwide seroprevalence of cytomegalovirus: a systematic review and meta-analysis. Rev Med Virol 2019;29:e2034. https://doi.org/10.1002/rmv.2034.

    Article  PubMed  Google Scholar 

  2. 2.

    Taylor-Wiedeman J, Sissons JGP, Borysiewicz LK, Sinclair JH. Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J General Virol 1991;72:2059–2064. https://doi.org/10.1099/0022-1317-72-9-2059.

    CAS  Article  Google Scholar 

  3. 3.

    Fletcher JM, Prentice HG, Grundy JE. Natural killer cell lysis of cytomegalovirus (cmv)-infectedcells correlates with virally induced changes in cell surfacelymphocyte function-associated antigen-3 (lfa-3)expression and not with the cmv-induced down-regulationof cell surface Class I HLA. J Immunol 1998;161:2365–2374

    CAS  PubMed  Google Scholar 

  4. 4.

    Reyburn HT, Mandelboim O, Valés-Gómez M, Davis DM, Pazmany L, Strominger JL. The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells. Nature 1997;386:514–517. https://doi.org/10.1038/386514a0.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Chopra KB et al. Progression of liver fibrosis in patients with chronic hepatitis C after orthotopic liver transplantation. Transplantation 2003;76:1487–1491. https://doi.org/10.1097/01.TP.0000088668.28950.7C.

    Article  PubMed  Google Scholar 

  6. 6.

    Sagedal S et al. Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival. Kidney Int 2004;66:329–337. https://doi.org/10.1111/j.1523-1755.2004.00735.x.

    Article  PubMed  Google Scholar 

  7. 7.

    Streblow D, Orloff S, Nelson J. Acceleration of allograft failure by cytomegalovirus. Curr Opin Immunol 2007;19:577–582. https://doi.org/10.1016/j.coi.2007.07.012.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Grattan MT, Moreno-Cabral C, Starnes VA. Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis.pdf. JAMA 1989;261:3561–3566

    CAS  Article  Google Scholar 

  9. 9.

    Speir E et al. Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science 1994;265:391–394

    CAS  Article  Google Scholar 

  10. 10.

    Melnick JL, Adam E, Debakey ME. Cytomegalovirus and atherosclerosis. Eur Heart J 2014;14:30–38

    Google Scholar 

  11. 11.

    Harkins L et al. Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet 2002;360:7

    Article  Google Scholar 

  12. 12.

    Shrestha BM, Darby C, Fergusson C, Lord R, Salaman JR, Moore RH. Cytomegalovirus causing acute colonic pseudo-obstruction in a renal transplant recipient. Postgraduate Med J 1996;72:429–430. https://doi.org/10.1136/pgmj.72.849.429.

    CAS  Article  Google Scholar 

  13. 13.

    Rotterdam H, Tsang P. Gastrointestinal disease in the immunocompromised patient. Hum Pathol 1994;25:1123–1140. https://doi.org/10.1016/0046-8177(94)90029-9.

    CAS  Article  PubMed  Google Scholar 

  14. 14.

    Mendez-Eirin E et al. Cumulative incidence of cytomegalovirus infection and disease after heart transplantation in the last decade: effect of preemptive therapy. Transp Proc 2012;44:2660–2662. https://doi.org/10.1016/j.transproceed.2012.09.035.

    CAS  Article  Google Scholar 

  15. 15.

    Muldoon J, O’Riordan K, Rao S, Abecassis M. ISCHEMIC COLITIS SECONDARY TO VENOUS THROMBOSIS: A Rare... : Transplantation. Transplantation 1996;61:1651–1653. https://doi.org/10.1097/00007890-199606150-00018.

    CAS  Article  PubMed  Google Scholar 

  16. 16.

    Roskell DE, Hyde GM, Campbell AP, Jewell DP, Gray W. HIV associated cytomegalovirus colitis as a mimic of inflammatory bowel disease. Gut 1995;37:148–150. https://doi.org/10.1136/gut.37.1.148.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  17. 17.

    Beaugerie L et al. Etiology and management of toxic megacolon in patients with human immunodeficiency virus infection. Gastroenterology 1994;107:858–863. https://doi.org/10.1016/0016-5085(94)90137-6.

    CAS  Article  PubMed  Google Scholar 

  18. 18.

    Diaz-Gonzalez V, Altemose G, Ogorek C, Pina I. Cytomegalovirus infection presenting as an apple-core lesion of the colon. J Heart Lung Transplant 1997;16:1171–1175

    CAS  PubMed  Google Scholar 

  19. 19.

    Klauber Enid, Briski Laurence E. Cytomegalovirus colitis in the immunocompetent host: an overview. Scandinavian J Infect Diseases 1998;30:559–564. https://doi.org/10.1080/00365549850161098.

    CAS  Article  Google Scholar 

  20. 20.

    Paya C et al. Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant 2004;4:611–620. https://doi.org/10.1111/j.1600-6143.2004.00382.x.

    CAS  Article  PubMed  Google Scholar 

  21. 21.

    Rasmussen L et al. Virus-specific IgG and IgM antibodies in normal and immunocompromised subjects infected with cytomegalovirus. J Infect Diseases 1982;145:191–199. https://doi.org/10.1093/infdis/145.2.191.

    CAS  Article  Google Scholar 

  22. 22.

    Fisher CE et al. Sensitivity of blood and tissue diagnostics for gastrointestinal cytomegalovirus disease in solid organ transplant recipients. Transplant Infect Disease 2016;18:372–380. https://doi.org/10.1111/tid.12531.

    CAS  Article  Google Scholar 

  23. 23.

    A. Crespo, M. G. F. M. ,. Gómez, M. ,. Monserrat, L. ,. Suarez, F. ,. Rodríguez, J. A. ,. Paniagua, M. J. ,. Cuesta, M. ,. Juffé, A. &. Castro-Beiras, A., “Cytomegalovirus Colitis Mimicking A Colonic Neoplasm or Ischemic Colitis 4 Years After Heart Transplantation,” Transplantation, vol. 66, pp. 1562–1565, 1998, doi: https://doi.org/10.1097/00007890-199812150-00023.

  24. 24.

    Fan X, Scott L, Qiu S, Raju GS, Shabot M. Colonic coinfection of histoplasma and cytomegalovirus mimicking carcinoma in a patient with HIV/AIDS. Gastrointest Endoscopy 2008;67:977–978. https://doi.org/10.1016/j.gie.2007.11.004.

    Article  Google Scholar 

  25. 25.

    Anderson VM, Greco MA, Recalde AL, Chandwani S, Church JA, Krasinski K. Intestinal cytomegalovirus ganglioneuronitis in children with human immunodeficiency virus infection. Pediatric Pathol 1990;10:167–174. https://doi.org/10.3109/15513819009067105.

    CAS  Article  Google Scholar 

  26. 26.

    Burns LJ, Pooley JC, Walsh DJ, Vercellotti GM, Weber ML, Kovacs A. Intercellular adhesion molecule-1 expression in endothelial cells is activated by cytomegalovirus immediate early proteins1. Transplantation 1999;67:137–144. https://doi.org/10.1097/00007890-199901150-00023.

    CAS  Article  PubMed  Google Scholar 

  27. 27.

    Sedmak D, Knight D, Vook N, Waldman J. Divergent patterns of ELAM-1, ICAM-1, and VCAM-1 expression on cytomegalovirus-infected endothelial cells. Transplantation 1994;58:1379–1385

    CAS  PubMed  Google Scholar 

  28. 28.

    Dieterich DT et al. Ganciclovir treatment of cytomegalovirus colitis in AIDS: a randomized, double-blind, placebo-controlled multicenter study. J Infect Dis 1993;167:278–282. https://doi.org/10.1093/infdis/167.2.278.

    CAS  Article  PubMed  Google Scholar 

  29. 29.

    Mowat AM, Agace WW. Regional specialization within the intestinal immune system. Nat Rev Immunol 2014;14:667–685. https://doi.org/10.1038/nri3738.

    CAS  Article  PubMed  Google Scholar 

  30. 30.

    Åsberg A et al. Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant 2007;7:2106–2113. https://doi.org/10.1111/j.1600-6143.2007.01910.x.

    CAS  Article  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to H. Kassam.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sahni, S., Kassam, H., Yaghooti, N. et al. Cure My Virus: Hematemesis and Melena in a Transplant Recipient. Dig Dis Sci (2021). https://doi.org/10.1007/s10620-021-06838-1

Download citation