Digestive Diseases and Sciences

, Volume 64, Issue 1, pp 25–38 | Cite as

Research Progress on the Relationship Between Acute Pancreatitis and Calcium Overload in Acinar Cells

  • Siqing Feng
  • Qiongqiong Wei
  • Qing Hu
  • Xiaomei Huang
  • Xi Zhou
  • Gang Luo
  • Mingming DengEmail author
  • Muhan LüEmail author


Acute pancreatitis is a human disease with multiple causes that leads to autodigestion of the pancreas. There is sufficient evidence to support the key role of sustained increase in cytosolic calcium concentrations in the early pathogenesis of the disease. To clarify the mechanism of maintaining calcium homeostasis in the cell and pathological processes caused by calcium overload would help to research directly targeted therapeutic agents. We will specifically review the following: intracellular calcium homeostasis and regulation, the occurrence of calcium overload in acinar cells, the role of calcium overload in the pathogenesis of AP, the treatment strategy proposed for calcium overload.


Pancreatitis Acinar cells Calcium Pathophysiology Therapy 



Acute pancreatitis




Pancreatic acinar cells


Extracellular Ca2+ concentration


The cytosolic Ca2+ concentration


Plasma membrane


Endoplasmic reticulum


Sarcoplasmic reticulum


Inositol 1,4,5-trisphosphate


InsP3 receptors


Ryanodine receptors


Fatty acid ethyl esters






InsP3-induced Ca2+ release


The type 1 InsP3R


The type 2 InsP3R


The type 3 InsP3R


Adenosine triphosphate




Zymogen granules


Cyclic ADP ribose


Calcium-induced calcium release


Sphingolipid Ca2+ release-mediating protein of the endoplasmic reticulum


Voltage-operated Ca2+ channels


Store-operated Ca2+ channels


Transient receptor potential channel


Stromal interaction molecule 1




Receptor-operated Ca2+ channels


Protein kinase C




Ca2+-ATPase on the plasma membrane


Intracellular calcium concentration


Na+/Ca2+ exchange


SR/ER Ca2+-ATPase


Trypsinogen-activating peptide


Mitochondrial permeability transition pore


Phospholipase A2


Thromboxane A2




Platelet-activating factor


Xanthine dehydrogenase


Xanthine oxidase


Oxygen free radicals


Reactive oxygen species


Calcium release activation of calcium




Soluble adenylyl cyclase


Cyclic adenosine monophosphate


Lactate dehydrogenase

Cyp D

Cyclophilin D


Pancreatic acinar cells


Mitochondrial membrane potential



This work was supported by the Affiliated Hospital of Southwest Medical University.


This article was funded by the following fund project: “The role and mechanism of calcium channels in hyperlipidemia acute pancreatitis,” project number: 2015LZCYD-S04 (6/15).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Siqing Feng
    • 1
  • Qiongqiong Wei
    • 1
  • Qing Hu
    • 2
  • Xiaomei Huang
    • 1
  • Xi Zhou
    • 2
  • Gang Luo
    • 2
  • Mingming Deng
    • 2
    Email author
  • Muhan Lü
    • 2
    Email author
  1. 1.Southwest Medical UniversityLuzhouChina
  2. 2.Department of GastroenterologyThe Affiliated Hospital of Southwest Medical UniversityLuzhouChina

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