Skip to main content
SpringerLink
Log in

Cyclic Change of Sphincter of Oddi Motility and Its Relationship with Small Bowel Migrating Motor Complex in Humans

  • Original Article
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Background

Several animal and human studies have reported that sphincter of Oddi (SO) motility shows cyclical changes during the fasting state. However, to date, the relationship between the SO motility and the migrating motor complex (MMC) of the small bowel (SB) remains unclear in humans.

Aims

We observed SO motility over a long study period and evaluated its relationship with the MMC of the SB in humans using percutaneous long-term manometry.

Methods

Our study included patients with hepatolithiasis who required percutaneous transhepatic catheter placement and subsequently underwent choledochoscopy and stone removal. Long-term percutaneous transhepatic SO manometry was performed after complete stone removal. SO and SB motility were simultaneously recorded.

Results

SO motility showed cyclical phasic changes with periodic high-frequency contractions similar to the MMC contractions of the SB. All high-frequency contractions of the SO coincided with phase III contractions of the MMC of the SB. The proportions of phase III contractions of SO and SB were similar, but the proportions of phase I (P = 0.001) and phase II (P = 0.002) contractions were significantly different. The mean basal SO pressure was observed to significantly increase in phase III compared to phase I (P = 0.001) and phase II (P = 0.001) contractions.

Conclusions

SO motility in humans showed cyclical phasic changes closely coordinated with the MMC of the SB in a fasting state; however, the proportion of phases differed between the SO and the SB. The basal pressure significantly increased during physiological high-frequency phase III contractions of the SO.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Honda R, Toouli J, Dodds WJ, Sarna S, Hogan WJ, Itoh Z. Relationship of sphincter of Oddi spike bursts to gastrointestinal myoelectric activity in conscious opossums. J Clin Invest. 1982;69:770–778.

    Article  CAS  Google Scholar 

  2. Scott RB, Strasberg SM, El-Sharkawy TY, Diamant NE. Fasting canine biliary secretion and the sphincter of Oddi. Gastroenterology. 1984;87:793–804.

    CAS  PubMed  Google Scholar 

  3. Coelho JC, Moody FG, Senninger N. A new method for correlating pancreatic and biliary duct pressures and sphincter of Oddi electromyography. Surgery. 1985;97:342–349.

    CAS  PubMed  Google Scholar 

  4. Takahashi I, Dodds WJ, Itoh Z, Hogan WJ, Kern MK. Influence of transsphincteric fluid flow on spike burst rate of the opossum sphincter of Oddi. Gastroenterology. 1984;87:1292–1298.

    CAS  PubMed  Google Scholar 

  5. Akita Y, Nimura Y, Yasui A. Percutaneous transhepatic manometry of sphincter of Oddi. Dig Dis Sci. 1991;36:1410–1417. https://doi.org/10.1007/BF01296808.

    Article  CAS  Google Scholar 

  6. Torsoli A, Corazziari E, Habib FI, et al. Frequencies and cyclical pattern of the human sphincter of Oddi phasic activity. Gut. 1986;27:363–369.

    Article  CAS  Google Scholar 

  7. Worthley CS, Baker RA, Iannos J, Saccone GT, Toouli J. Human fasting and postprandial sphincter of Oddi motility. Br J Surg. 1989;76:709–714.

    Article  CAS  Google Scholar 

  8. Yuasa N, Nimura Y, Yasui A, Akita Y, Odani K. Sphincter of Oddi motility in patients with bile duct stones. A comparative study using percutaneous transhepatic manometry. Dig Dis Sci. 1994;39:257–267. https://doi.org/10.1007/BF02090195.

    Article  CAS  Google Scholar 

  9. Kuo KK, Utsunomiya N, Nabae T, et al. Sphincter of Oddi motility in patients with hepatolithiasis and common bile duct stones. Dig Dis Sci. 2000;45:1714–1718. https://doi.org/10.1023/A:1005546631237.

    Article  CAS  Google Scholar 

  10. Gorard DA, Vesselinova-Jenkins CK, Libby GW, Farthing MJ. Migrating motor complex and sleep in health and irritable bowel syndrome. Dig Dis Sci. 1995;40:2383–2389. https://doi.org/10.1007/BF02063242.

    Article  CAS  Google Scholar 

  11. Gregg JA, Antal RD. Rhythm abnormalities of the biliary and pancreatic sphincters: diagnosis by endoscopic manometry. Am J Surg. 1984;148:602–606.

    Article  CAS  Google Scholar 

  12. Hogan WJ, Geenen J, Venu R, Dodds WJ, Helm J, Toouli J. Abnormally rapid phasic contractions of the human sphincter of Oddi (tachyoddia). Gastroenterology. 1983;84:1189.

    Google Scholar 

  13. Corazziari E, Shaffer EA, Hogan WJ, Sherman S, Toouli J. Functional disorders of the biliary tract and pancreas. Gut.. 1999;45:Ii48–Ii54.

    Article  Google Scholar 

  14. Behar J, Corazziari E, Guelrud M, Hogan W, Sherman S, Toouli J. Functional gallbladder and sphincter of oddi disorders. Gastroenterology. 2006;130:1498–1509.

    Article  Google Scholar 

  15. Cotton PB, Elta GH, Carter CR, Pasricha PJ, Corazziari ES. Gallbladder and sphincter of Oddi disorders. Gastroenterology. 2016;150:1420–1429.

    Article  Google Scholar 

  16. Guelrud M, Mendoza S, Vicent S, Gomez M, Villalta B. Pressures in the sphincter of Oddi in patients with gallstones, common duct stones, and recurrent pancreatitis. J Clin Gastroenterol. 1983;5:37–41.

    Article  CAS  Google Scholar 

  17. Funch-Jensen P, Kraglund K, Djurhuus JC. The influence of measuring catheter diameter on direct manometry in the canine sphincter of Oddi. Scand J Gastroenterol. 1984;19:926–930.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 443-380, South Korea

    Byung Moo Yoo, Jin Hong Kim, Min Jae Yang, Jae Chul Hwang, Soon Sun Kim, Joon Koo Kang, Sun Gyo Lim, Sung Jae Shin, Jae Youn Cheong & Kee Myung Lee

  2. Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 550 N. University Boulevard, Suite 1634, Indianapolis, IN, 46202, USA

    Glen A. Lehman

Authors
  1. Byung Moo Yoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jin Hong Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Min Jae Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Glen A. Lehman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jae Chul Hwang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Soon Sun Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Joon Koo Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sun Gyo Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sung Jae Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jae Youn Cheong
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Kee Myung Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jin Hong Kim.

Ethics declarations

Conflict of interest

The authors declare no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yoo, B.M., Kim, J.H., Yang, M.J. et al. Cyclic Change of Sphincter of Oddi Motility and Its Relationship with Small Bowel Migrating Motor Complex in Humans. Dig Dis Sci 63, 3425–3433 (2018). https://doi.org/10.1007/s10620-018-5276-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-018-5276-0

Keywords

Search

Navigation