Digestive Diseases and Sciences

, Volume 63, Issue 12, pp 3262–3271 | Cite as

A Survey of Expert Practice and Attitudes Regarding Advanced Imaging Modalities in Surveillance of Barrett’s Esophagus

  • Jorge D. Machicado
  • Samuel Han
  • Rena H. Yadlapati
  • Violette C. Simon
  • Bashar J. Qumseya
  • Shahnaz Sultan
  • Vladimir M. Kushnir
  • Sri Komanduri
  • Amit Rastogi
  • V. Raman Muthusamy
  • Rehan Haidry
  • Krish Ragunath
  • Rajvinder Singh
  • Hazem T. Hammad
  • Nicholas J. Shaheen
  • Sachin WaniEmail author
Original Article



Published guidelines do not address what the minimum incremental diagnostic yield (IDY) for detection of dysplasia/cancer is required over the standard Seattle protocol for an advanced imaging modality (AIM) to be implemented in routine surveillance of Barrett’s esophagus (BE) patients. We aimed to report expert practice patterns and attitudes, specifically addressing the minimum IDY in the use of AIMs in BE surveillance.


An international group of BE experts completed an anonymous electronic survey of domains relevant to surveillance practice patterns and use of AIMs. The evaluated AIMs were conventional chromoendoscopy (CC), virtual chromoendoscopy (VC), volumetric laser endomicroscopy (VLE), confocal laser endomicroscopy (CLE), and wide-area transepithelial sampling (WATS3D). Responses were recorded using five-point balanced Likert items and analyzed as continuous variables.


The survey response rate was 84% (61/73)—41 US and 20 non-US. Experts were most comfortable with and routinely use VC and CC, and least comfortable with and rarely use VLE, CLE, and WATS3D. Experts rated data from randomized controlled trials (1.4 ± 0.9) and guidelines (2.6 ± 1.2) as the two most influential factors for implementing AIMs in clinical practice. The minimum IDY of AIMs over standard biopsies to be considered of clinical benefit was lowest for VC (15%, IQR 10–29%) and highest for VLE (30%, IQR 20–50%). Compared to US experts, non-US experts reported higher use of CC for BE surveillance (p < 0.001).


These results should inform benchmarks that need to be met for guidelines to recommend the routine use of AIMs in the surveillance of BE patients.


Barrett’s esophagus Surveillance Advanced imaging modalities Practice patterns 



This study was supported by the University of Colorado Department of Medicine Outstanding Early Scholars Program. SK is a consultant for Boston Scientific and Medtronic; AR is a consultant for Olympus, Research support–Olympus; HH is a consultant Medtronic; SW is a consultant for Boston Scientific and Medtronic.

Author’s contribution

Jorge D. Machicado, Samuel Han, Nicholas J. Shaheen, and Sachin B. Wani were involved in study concept and design. Jorge D. Machicado, Samuel Han, Violette C. Simon, and Sachin B. Wani were involved in acquisition of data. Jorge D. Machicado contributed to statistical analysis. Jorge D. Machicado and Sachin B. Wani drafted the manuscript. All authors were involved in data interpretation, review of manuscript for important intellectual content, final approval of the manuscript. Guarantor of the article: Sachin Wani, MD.

Compliance with ethical standards

Conflict of interest

The other authors declare no conflicts of interest.

Supplementary material

10620_2018_5257_MOESM1_ESM.pdf (65 kb)
Supplementary material 1 (PDF 64 kb)
10620_2018_5257_MOESM2_ESM.docx (32 kb)
Supplementary material 2 (DOCX 31 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Jorge D. Machicado
    • 1
  • Samuel Han
    • 1
  • Rena H. Yadlapati
    • 1
  • Violette C. Simon
    • 1
  • Bashar J. Qumseya
    • 2
  • Shahnaz Sultan
    • 3
  • Vladimir M. Kushnir
    • 4
  • Sri Komanduri
    • 5
  • Amit Rastogi
    • 6
  • V. Raman Muthusamy
    • 7
  • Rehan Haidry
    • 8
  • Krish Ragunath
    • 9
  • Rajvinder Singh
    • 10
  • Hazem T. Hammad
    • 1
  • Nicholas J. Shaheen
    • 11
  • Sachin Wani
    • 1
    Email author
  1. 1.University of Colorado Anschutz Medical CenterAuroraUSA
  2. 2.Archbold Medical CenterThomasvilleUSA
  3. 3.Minneapolis VA Health Care SystemMinneapolisUSA
  4. 4.Washington UniversitySt. LouisUSA
  5. 5.Northwestern UniversityChicagoUSA
  6. 6.University of Kansas School of MedicineKansas CityUSA
  7. 7.University of California in Los AngelesLos AngelesUSA
  8. 8.University College HospitalLondonUK
  9. 9.University of NottinghamNottinghamUK
  10. 10.University of AdelaideAdelaideAustralia
  11. 11.University of North CarolinaChapel HillUSA

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