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Digestive Diseases and Sciences

, Volume 63, Issue 12, pp 3417–3424 | Cite as

A Positive Correlation Between Gastric and Esophageal Dysmotility Suggests Common Causality

  • Thomas A. ZikosEmail author
  • John O. Clarke
  • George Triadafilopoulos
  • Kirsten A. Regalia
  • Irene S. Sonu
  • Nielsen Q. Fernandez-Becker
  • Monica C. Nandwani
  • Linda A. Nguyen
Original Article

Abstract

Background

Gastric and esophageal dysmotility syndromes are some of the most common motility diagnoses, but little is known about their interrelationship.

Aims

The aim of our study was to determine if a correlation exists between gastric and esophageal dysmotility syndromes.

Methods

We reviewed the records of all patients who underwent both solid gastric emptying scintigraphy (GES) and high-resolution esophageal manometry (HRM) within a 2 year period, with both done between August 2012 and August 2017. All GESs were classified as either rapid, normal, or delayed. All HRMs were classified according to the Chicago Classification 3.0. Correlations were assessed using Fisher’s exact test and multiple logistic regression.

Results

In total, 482 patients met inclusion criteria. Of patients with a normal, delayed, and rapid GES, 53.1, 64.5, and 77.3% had an abnormal HRM, respectively (p < 0.05 vs. normal GES). Likewise, patients with an abnormal HRM were more likely to have an abnormal GES (54.9 vs. 41.8%, p = 0.005). Multiple logistic regression showed abnormal GES [odds ratio (OR) 2.14], age (OR 1.013), scleroderma (OR 6.29), and dysphagia (OR 2.63) were independent predictors of an abnormal HRM. Likewise, an abnormal HRM (OR 2.11), diabetes (OR 1.85), heart or lung transplantation (OR 2.61), and autonomic dysfunction (OR 2.37) were independent predictors of an abnormal GES.

Conclusions

The correlation between an abnormal GES and HRM argues for common pathogenic mechanisms of these motility disorders, and possibly common future treatment options. Clinicians should have a high index of suspicion for another motility disorder if one is present.

Keywords

Gastroparesis Gastric emptying Esophageal motility disorder Diabetes mellitus Lung transplantation Enteric nervous system 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Thomas A. Zikos
    • 1
    Email author
  • John O. Clarke
    • 1
  • George Triadafilopoulos
    • 1
  • Kirsten A. Regalia
    • 1
  • Irene S. Sonu
    • 1
  • Nielsen Q. Fernandez-Becker
    • 1
  • Monica C. Nandwani
    • 1
  • Linda A. Nguyen
    • 1
  1. 1.Stanford Multidimensional Program for Innovation and Research in the Esophagus (S-MPIRE), Division of Gastroenterology and HepatologyStanford University School of MedicineStanfordUSA

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