Abstract
Background
Biliary drainage via endoscopic retrograde cholangiopancreatography (ERCP) is the first-line treatment for acute cholangitis. Despite the established effectiveness of urgent biliary drainage in patients with severe acute cholangitis, the indication of this procedure for non-severe acute cholangitis is controversial.
Aims
To assess the safety of elective drainage (≥ 12 h of admission) for non-severe acute cholangitis.
Methods
We retrospectively identified 461 patients with non-severe acute cholangitis who underwent endoscopic biliary drainage. Using linear regression models with adjustment for a variety of potential confounders, we compared elective versus urgent biliary drainage (< 12 h of admission) in terms of clinical outcomes. The primary outcome was the length of stay.
Results
There were 98 and 201 patients who underwent elective and urgent biliary drainage, respectively. The median length of stay was 11 days in both groups (P = 0.52). The timing of ERCP was not associated with length of stay in the multivariable model (P = 0.52). Secondary outcomes including in-hospital mortality and recurrence of cholangitis were not different between the groups.
Conclusions
Elective biliary drainage was not associated with worse clinical outcomes of non-severe acute cholangitis as compared to urgent drainage. Further investigation is warranted to justify the elective drainage for non-severe cholangitis.
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References
Kogure H, Tsujino T, Yamamoto K, et al. Fever-based antibiotic therapy for acute cholangitis following successful endoscopic biliary drainage. J Gastroenterol. 2011;46:1411–1417.
van Santvoort HC, Besselink MG, de Vries AC, et al. Early endoscopic retrograde cholangiopancreatography in predicted severe acute biliary pancreatitis: a prospective multicenter study. Ann Surg. 2009;250:68–75.
Umefune G, Kogure H, Hamada T, et al. Procalcitonin is a useful biomarker to predict severe acute cholangitis: a single-center prospective study. J Gastroenterol. 2017;52:734–745.
Salek J, Livote E, Sideridis K, et al. Analysis of risk factors predictive of early mortality and urgent ERCP in acute cholangitis. J Clin Gastroenterol. 2009;43:171–175.
Pang YY, Chung YA. Predictors for emergency biliary decompression in acute cholangitis. Eur J Gastroenterol Hepatol. 2006;18:727–731.
Tsujino T, Sugita R, Yoshida H, et al. Risk factors for acute suppurative cholangitis caused by bile duct stones. Eur J Gastroenterol Hepatol. 2007;19:585–588.
Ramchandani M, Pal P, Reddy DN. Endoscopic management of acute cholangitis as a result of common bile duct stones. Dig Endosc. 2017;29(Suppl 2):78–87.
Tsuchiya T, Sofuni A, Tsuji S, et al. Endoscopic management of acute cholangitis according to the TG13. Dig Endosc.. 2017;29(Suppl 2):94–99.
Okamoto K, Takada T, Strasberg SM, et al. TG13 management bundles for acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:55–59.
Kiriyama S, Takada T, Strasberg SM, et al. New diagnostic criteria and severity assessment of acute cholangitis in revised Tokyo Guidelines. J Hepatobiliary Pancreat Sci. 2012;19:548–556.
Miura F, Takada T, Strasberg SM, et al. TG13 flowchart for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:47–54.
Miura F, Okamoto K, Tokyo Takada T, Takada T, Tokyo Guidelines, et al. Iinitial management of acute biliary infection and flowchart for acute cholangitis. J Hepatobiliary Pancreat Sci. 2018;. https://doi.org/10.1002/jhbp.509.
Navaneethan U, Gutierrez NG, Jegadeesan R, et al. Delay in performing ERCP and adverse events increase the 30-day readmission risk in patients with acute cholangitis. Gastrointestl Endosc. 2013;78:81–90.
Khashab MA, Tariq A, Tariq U, et al. Delayed and unsuccessful endoscopic retrograde cholangiopancreatography are associated with worse outcomes in patients with acute cholangitis. Clin Gastroenterol Hepatol. 2012;10:1157–1161.
Lee F, Ohanian E, Rheem J, et al. Delayed endoscopic retrograde cholangiopancreatography is associated with persistent organ failure in hospitalised patients with acute cholangitis. Aliment Pharmacol Ther. 2015;42:212–220.
Jang SE, Park SW, Lee BS, et al. Management for CBD stone-related mild to moderate acute cholangitis: urgent versus elective ERCP. Dig Dis Sci. 2013;58:2082–2087.
Shaheen AA, Kaplan GG, Myers RP. Weekend versus weekday admission and mortality from gastrointestinal hemorrhage caused by peptic ulcer disease. Clin Gastroenterol Hepatol.. 2009;7:303–310.
Palmer WL, Bottle A, Davie C, et al. Dying for the weekend: a retrospective cohort study on the association between day of hospital presentation and the quality and safety of stroke care. Arch Neurol. 2012;69:1296–1302.
Ananthakrishnan AN, McGinley EL, Saeian K. Outcomes of weekend admissions for upper gastrointestinal hemorrhage: a nationwide analysis. Clin Gastroenterol Hepatol. 2009; 7:296–302e291.
Gallerani M, Imberti D, Ageno W, et al. Higher mortality rate in patients hospitalised for acute pulmonary embolism during weekends. Thromb Haemost. 2011;106:83–89.
Kostis WJDK, Marcella SW, Shao YH, et al. Weekend versus weekday admission and mortality from myocardial infarction. N Engl J Med. 2007;356:1099–1109.
Hamada T, Yasunaga H, Nakai Y, et al. No weekend effect on outcomes of severe acute pancreatitis in Japan: data from the diagnosis procedure combination database. J Gastroenterol. 2016;51:1063–1072.
Inamdar S, Sejpal DV, Ullah M, et al. Weekend vs. weekday admissions for cholangitis requiring an ERCP: comparison of outcomes in a national cohort. Am J Gastroenterol. 2016;111:405–410.
Tabibian JH, Yang JD, Baron TH, et al. Weekend admission for acute cholangitis does not adversely impact clinical or endoscopic outcomes. Dig Dis Sci. 2016;61:53–61.
Parikh ND, Issaka R, Lapin B, et al. Inpatient weekend ERCP is associated with a reduction in patient length of stay. Am J Gastroenterol. 2014;109:465–470.
Hou LA, Laine L, Motamedi N, et al. Optimal timing of endoscopic retrograde cholangiopancreatography in acute cholangitis. J Clin Gastroenterol. 2017;51:534–538.
Mok SR, Mannino CL, Malin J, et al. Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). J Interv Gastroenterol. 2012;2:161–167.
Cotton PB, Eisen GM, Aabakken L, et al. A lexicon for endoscopic adverse events: report of an ASGE workshop. Gastrointest Endosc. 2010;71:446–454.
Owens WD, Felts JA, Spitznagel EL Jr. ASA physical status classifications: a study of consistency of ratings. Anesthesiology. 1978;49:239–243.
Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–383.
Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–458.
Tan M, Schaffalitzky de Muckadell OB, Laursen SB. Association between early ERCP and mortality in patients with acute cholangitis. Gastrointest Endosc. 2017;. https://doi.org/10.1016/j.gie.2017.04.009.
Isayama H, Yasuda I, Tan D. Current strategies for endoscopic management of acute cholangitis. Dig Endosc. 2017;29(Suppl 2):70–77.
Kiriyama S, Takada T, Hwang TL, et al. Clinical application and verification of the TG13 diagnostic and severity grading criteria for acute cholangitis: an international multicenter observational study. J Hepatobiliary Pancreat Sci. 2017;24:329–337.
Kiriyama S, Kozaka K, Takada T, et al. Diagnostic and severity grading criteria for acute cholangitis in the Tokyo Guidelines 2018. J Hepatobiliary Pancreat Sci. 2017;. https://doi.org/10.1002/jhbp.512.
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RH, TH, and YN contributed to conception and design of the study, analysis and interpretation of the data, and drafting of the article. HK, RU, NT, SM, TS, TS, TT, KI, KS, TS, MT, HI, YN, and KK contributed to critical revision of the article for important intellectual content. All authors contributed to the final approval of the article.
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Hakuta, R., Hamada, T., Nakai, Y. et al. No Association of Timing of Endoscopic Biliary Drainage with Clinical Outcomes in Patients with Non-severe Acute Cholangitis. Dig Dis Sci 63, 1937–1945 (2018). https://doi.org/10.1007/s10620-018-5058-8
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DOI: https://doi.org/10.1007/s10620-018-5058-8