Skip to main content

Advertisement

SpringerLink
Log in

Latent Hepatitis Virus Reactivation Due to Drug Reaction: DRESSed to Kill?

  • UNM Clinical Case Conferences
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Crado PR, Criado RFJ, Avancini JdM, Santi CG. Drug reaction with eosinophilia and systemic symptoms (DRESS)/Drug-induced Hypersensitivity Syndrome (DIHS): a review of current concepts. Ann Bras Dermatol. 2012;87:435–449.

    Article  Google Scholar 

  2. Whitley RJ. In: Baron S, eds. Medical Microbiology. 4th ed. Galveston, TX: University of Texas Medical Branch at Galveston; Chapter 68; 1996.

  3. Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br J Dermatol. 2007;156:1083–1084.

    Article  CAS  PubMed  Google Scholar 

  4. International Committee on Taxonomy of Viruses. ICTV Master Species List 2011.

  5. Johnson S, Mathews S, Hudnall SD. Human herpesvirus 6 lymphadenitis in drug rash with eosinophilia and systemic symptoms syndrome: a lymphoma mimic. Histopathology. 2017;70:1166–1170.

    Article  PubMed  Google Scholar 

  6. Ferrero NA, Pearson KC, Zedek DC, Morrell DS. Case report of drug rash with eosinophilia and systemic symptoms demonstrating human herpesvirus-6 reactivation. Pediatr Dermatol. 2013;30:608–613.

    Article  PubMed  Google Scholar 

  7. Isaacson E, Glaser CA, Forghani B, Amad Z, et al. Evidence of human herpesvirus-6 infection in 4 immunocompetent patients with encephalitis. Clin Infect Dis. 2005;40:890–893.

    Article  PubMed  Google Scholar 

  8. Challoner PB, Smith KT, Parker JD, MacLeod DL, et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci USA. 1995;92:7440–7444.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Alvarez-Lafuente R, De las Heras V, BartoloméM Picazo JJ, Arroy R. Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection. Arch Neurol. 2004;61:1523–1527.

    Article  PubMed  Google Scholar 

  10. Härmä M, Höckerstedt K, Lautenschlager I. Human herpesvirus-6 and acute liver failure. Transplantation. 2003;76:536–539.

    Article  PubMed  Google Scholar 

  11. Charnot-Katsikas A, Baewer D, Cook L, David MZ. Fulminant hepatic failure attributed to infection with human herpesvirus 6 (HHV-6) in an immunocompetent woman: a case report and review of the literature. J Clin Virol. 2016;75:27–32.

    Article  PubMed  Google Scholar 

  12. Picard D, Janela B, Descamps V, D’Incan M, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response. Sci Transl Med. 2010;2:46ra62. https://doi.org/10.1126/scitranslmed.30011.

    Article  PubMed  Google Scholar 

  13. Tuqan W, Lee S, Hanson J, McCarthy D. Carbamazepine-Associated Hypersensitivity Colitis. Dig Dis Sci. 2018;63:334–337. https://doi.org/10.1007/s10620-017-4881-7.

    Article  PubMed  Google Scholar 

  14. Boussiotis VA. Molecular and biochemical aspects of the PD-1 checkpoint pathway. N Engl J Med. 2016;375:1767–1778.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Blumberg BM, Mock DJ, Powers JM, Ito M, et al. The HHV6 paradox: ubiquitous commensal or insidious pathogen? A two-step in situ PCR approach. J Clin Virol. 2000;16:159–176.

    Article  CAS  PubMed  Google Scholar 

  16. Fotheringham J, Akhyani N, Vortmeyer A, Donati D, et al. Detection of active human herpesvirus-6 infection in the brain: correlation with polymerase chain reaction detection in cerebrospinal fluid. Infect Dis. 2007;195:450–454.

    Article  CAS  Google Scholar 

  17. Flamand L, Gravel A, Boutolleau D, Alvarez-Lafuente R, et al. Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum. J Clin Microbiol. 2008;46:2700–2706.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Traylen CM, Patel HR, Fondaw W, Mahatme S, et al. Virus Reactivation: a panoramic view in human infections. Future Virol. 2011;6:451–463.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Asthana AK, Lubel JS. Reactivation of latent viruses after treatment with biological therapies. Virus Adapt Treat. 2014;6:1–10.

    CAS  Google Scholar 

  20. Lopez-Serrano P, de la Fuente-Briongos E, Carrera- Alonso E, Perez-Calle JL, et al. Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: when and how to apply prophylaxis, with a special focus on corticosteroid therapy. World J Hepatol. 2015;7:539–547.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, University of New Mexico School of Medicine, 1 University of New Mexico, MSC10-5550, Albuquerque, NM, 87131, USA

    David Alexanian, Aleksandr Birg, Nicholas Volpicelli & Denis McCarthy

  2. Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA

    Joseph Glass

Authors
  1. David Alexanian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aleksandr Birg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nicholas Volpicelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Joseph Glass
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Denis McCarthy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David Alexanian.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alexanian, D., Birg, A., Volpicelli, N. et al. Latent Hepatitis Virus Reactivation Due to Drug Reaction: DRESSed to Kill?. Dig Dis Sci 63, 1143–1147 (2018). https://doi.org/10.1007/s10620-018-5028-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-018-5028-1

Keywords

Search

Navigation