Digestive Diseases and Sciences

, Volume 61, Issue 7, pp 2142–2144 | Cite as

NOD2 Risk Variants and Pathological Bacterial Translocation in Decompensated Cirrhosis

  • Tony Bruns
  • Philipp A. Reuken
  • Sven Stengel
  • Ludmila Gerber
  • Beate Appenrodt
  • Johannes H. Schade
  • Frank Lammert
  • Stefan Zeuzem
  • Andreas Stallmach


Turkey Cirrhotic Patient Medical Faculty Ascitic Fluid Bacterial Translocation 


Compliance with ethical standards

Conflict of interest



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    Harputluoglu MMM, Dertli R, Otlu B, et al. Nucleotide-binding oligomerization domain-containing protein 2 variants in patients with spontaneous bacterial peritonitis. Dig Dis Sci. (Epub ahead of print). doi: 10.1007/s10620-015-4024-y.
  2. 2.
    Bruns T, Peter J, Reuken PA, et al. NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis. Liver Int. 2012;32:223–230.CrossRefPubMedGoogle Scholar
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    Appenrodt B, Grünhage F, Gentemann MG, Thyssen L, Sauerbruch T, Lammert F. Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis. Hepatology. 2010;51:1327–1333.CrossRefPubMedGoogle Scholar
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    Ozen SC, Dagli U, Kiliç MY, et al. NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms in Turkish patients with inflammatory bowel disease. J Gastroenterol. 2006;41:304–310.CrossRefPubMedGoogle Scholar
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    Bruns T, Reuken PA, Stengel S, et al. The prognostic significance of bacterial DNA in patients with decompensated cirrhosis and suspected infection. Liver Int. 2016. doi: 10.1111/liv.13095.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.The Integrated Research and Treatment Center for Sepsis Control and Care (CSCC)Jena University HospitalJenaGermany
  2. 2.Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases)Jena University HospitalJenaGermany
  3. 3.Department of Internal Medicine IFrankfurt University HospitalFrankfurtGermany
  4. 4.Department of Internal Medicine IISaarland University HospitalHomburgGermany

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