Eosinophilic Esophagitis in Children and Its Relationship with Parental Allergies: Texas Children’s Hospital Experience
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Eosinophilic esophagitis (EoE) is an allergen-mediated, clinicopathological condition affecting all ages. The characteristics of children with EoE in the southwestern USA have not been fully described. Furthermore, very little is known about the relationship between parental allergies and risk of EoE in their offspring in this patient population.
To characterize children with EoE and to examine the relationship between prevalence of parental allergies and occurrence of EoE in their offspring at a single referral pediatric center in the southwestern USA.
Demographic and clinical information of 126 children (≤18 years of age) with EoE was abstracted in a pre-determined data extraction form and analyzed. The allergy history was collected from biological parents of 61 children (parent–child cluster) with EoE in a standardized questionnaire and analyzed.
The median age at presentation was 8 years (interquartile range 4–13). The majority of our patients were male (71 %) and Caucasian (59 %). Overall, 84 % of children reported allergies. Prevalence of food allergy was significantly higher compared to environmental allergies (P = 0.001). At least 46 % of parents reported allergies. A significantly higher proportion of fathers had developed allergies during their childhood compared to adulthood (P = 0.03).
The characteristics of EoE in our patients were similar to those reported from other parts of the country. Childhood onset of paternal allergies appears to be a risk factor for occurrence of EoE in their offspring. Additional research to elucidate the relationship between parental allergies and occurrence of EoE in their offspring is warranted.
KeywordsEosinophilic esophagitis Epidemiology Food allergy Parent–child cluster Parental allergies
G.H. is supported by NIH T32-DK007664. Support from Digestive Diseases Research Core Center Program (P30 DK56338) is acknowledged.
Compliance with ethical standards
Conflict of interest
Authors declare no conflict of interest.
- 2.Branum AM, Lukacs SL. Food Allergy Among U.S. Children: Trends in Prevalence and Hospitalizations. NCHS Data Brief. 2008:1–8.Google Scholar
- 4.Dellon ES, Jensen ET, Martin CF, Shaheen NJ, Kappelman MD. Prevalence of eosinophilic esophagitis in the United States. Clin Gastroenterol Hepatol. 2014;12:589e1–596e1.Google Scholar
- 7.Jackson KD, Howie LD, Akinbami LJ. Trends in Allergic Conditions Among Children: United States, 1997–2011. NCHS Data Brief. 2013:1–8.Google Scholar
- 8.Murdock SH, Cline M, Zey M. The Children of the Southwest: Demographic and socioeconomic characteristics impacting the future of the Southwest and the United States. In: Big ideas: Children in the Southwest. Washington, DC: First Focus; 2012:11–29.Google Scholar