Digestive Diseases and Sciences

, Volume 61, Issue 2, pp 501–506 | Cite as

Eosinophilic Esophagitis in Children and Its Relationship with Parental Allergies: Texas Children’s Hospital Experience

  • Girish Hiremath
  • Darius Byramji
  • Ann Pacheco
  • Greg Constantine
  • Carla Davis
  • Robert Shulman
  • Anthony Olive
Original Article



Eosinophilic esophagitis (EoE) is an allergen-mediated, clinicopathological condition affecting all ages. The characteristics of children with EoE in the southwestern USA have not been fully described. Furthermore, very little is known about the relationship between parental allergies and risk of EoE in their offspring in this patient population.


To characterize children with EoE and to examine the relationship between prevalence of parental allergies and occurrence of EoE in their offspring at a single referral pediatric center in the southwestern USA.


Demographic and clinical information of 126 children (≤18 years of age) with EoE was abstracted in a pre-determined data extraction form and analyzed. The allergy history was collected from biological parents of 61 children (parent–child cluster) with EoE in a standardized questionnaire and analyzed.


The median age at presentation was 8 years (interquartile range 4–13). The majority of our patients were male (71 %) and Caucasian (59 %). Overall, 84 % of children reported allergies. Prevalence of food allergy was significantly higher compared to environmental allergies (P = 0.001). At least 46 % of parents reported allergies. A significantly higher proportion of fathers had developed allergies during their childhood compared to adulthood (P = 0.03).


The characteristics of EoE in our patients were similar to those reported from other parts of the country. Childhood onset of paternal allergies appears to be a risk factor for occurrence of EoE in their offspring. Additional research to elucidate the relationship between parental allergies and occurrence of EoE in their offspring is warranted.


Eosinophilic esophagitis Epidemiology Food allergy Parent–child cluster Parental allergies 



G.H. is supported by NIH T32-DK007664. Support from Digestive Diseases Research Core Center Program (P30 DK56338) is acknowledged.

Compliance with ethical standards

Conflict of interest

Authors declare no conflict of interest.

Supplementary material

10620_2015_3903_MOESM1_ESM.docx (20 kb)
Supplementary material 1 (DOCX 20 kb)


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Girish Hiremath
    • 1
  • Darius Byramji
    • 1
  • Ann Pacheco
    • 1
  • Greg Constantine
    • 2
  • Carla Davis
    • 3
  • Robert Shulman
    • 1
    • 4
  • Anthony Olive
    • 1
  1. 1.Pediatric Gastroenterology, Hepatology and Nutrition, Texas Children’s HospitalBaylor College of MedicineHoustonUSA
  2. 2.Baylor College of MedicineHoustonUSA
  3. 3.Pediatric Allergy, Immunology and Rheumatology, Texas Children’s HospitalBaylor College of MedicineHoustonUSA
  4. 4.Children’s Nutrition Research CenterBaylor College of MedicineHoustonUSA

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