Oxidative Stress Might Play a Role in Low Serum Vitamin D Associated Liver Fibrosis Among Patients with Autoimmune Hepatitis
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We have read with great interest the promising article by Efe et al.  recently published in your journal. The authors successfully demonstrated the role of Vitamin D in the hepatic fibrotic process and severe inflammation in patients with autoimmune hepatitis (AIH). Moreover, they stated that Vitamin D might be a potential biomarker for predicting treatment response and histological features in AIH. Although the authors discussed comprehensively possible links in this association, we would like to suggest an alternative mechanism relating Vitamin D to liver fibrosis, which we think may be important for a better understanding of the results presented in this study.
In their study, the authors give a detailed discussion relating Vitamin D and hepatic fibrosis in AIH. But it seems that the authors mainly attribute the possible connection between these two entities to immunological mechanisms, namely to T cell-mediated hepatic inflammation and liver damage. Although there is...
KeywordsNitric Oxide Liver Fibrosis Autoimmune Hepatitis Hepatic Inflammation Fibrosis Progression
Conflict of interest
- 11.Beyazit Y, Kocak E, Tanoglu A, et al. Oxidative stress might play a role in low serum vitamin D associated liver fibrosis among patients with autoimmune hepatitis. Dig Dis Sci. (Epub ahead of print). doi: 10.1007/s10620-015-3526-y.