Digestive Diseases and Sciences

, Volume 60, Issue 4, pp 1106–1108 | Cite as

Oxidative Stress Might Play a Role in Low Serum Vitamin D Associated Liver Fibrosis Among Patients with Autoimmune Hepatitis

  • Yavuz Beyazit
  • Erdem Kocak
  • Alpaslan Tanoglu
  • Murat Kekilli

Dear Editor

We have read with great interest the promising article by Efe et al. [1] recently published in your journal. The authors successfully demonstrated the role of Vitamin D in the hepatic fibrotic process and severe inflammation in patients with autoimmune hepatitis (AIH). Moreover, they stated that Vitamin D might be a potential biomarker for predicting treatment response and histological features in AIH. Although the authors discussed comprehensively possible links in this association, we would like to suggest an alternative mechanism relating Vitamin D to liver fibrosis, which we think may be important for a better understanding of the results presented in this study.

In their study, the authors give a detailed discussion relating Vitamin D and hepatic fibrosis in AIH. But it seems that the authors mainly attribute the possible connection between these two entities to immunological mechanisms, namely to T cell-mediated hepatic inflammation and liver damage. Although there is...


Nitric Oxide Liver Fibrosis Autoimmune Hepatitis Hepatic Inflammation Fibrosis Progression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest



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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Yavuz Beyazit
    • 1
  • Erdem Kocak
    • 1
  • Alpaslan Tanoglu
    • 2
  • Murat Kekilli
    • 3
  1. 1.Department of GastroenterologyCanakkale State HospitalCanakkaleTurkey
  2. 2.Department of GastroenterologyGATA Haydarpasa Training HospitalUskudar, IstanbulTurkey
  3. 3.Department of GastroenterologyAnkara Education and Research HospitalAnkaraTurkey

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