Advertisement

Digestive Diseases and Sciences

, Volume 60, Issue 4, pp 1106–1108 | Cite as

Oxidative Stress Might Play a Role in Low Serum Vitamin D Associated Liver Fibrosis Among Patients with Autoimmune Hepatitis

  • Yavuz Beyazit
  • Erdem Kocak
  • Alpaslan Tanoglu
  • Murat Kekilli
Correspondence

Dear Editor

We have read with great interest the promising article by Efe et al. [1] recently published in your journal. The authors successfully demonstrated the role of Vitamin D in the hepatic fibrotic process and severe inflammation in patients with autoimmune hepatitis (AIH). Moreover, they stated that Vitamin D might be a potential biomarker for predicting treatment response and histological features in AIH. Although the authors discussed comprehensively possible links in this association, we would like to suggest an alternative mechanism relating Vitamin D to liver fibrosis, which we think may be important for a better understanding of the results presented in this study.

In their study, the authors give a detailed discussion relating Vitamin D and hepatic fibrosis in AIH. But it seems that the authors mainly attribute the possible connection between these two entities to immunological mechanisms, namely to T cell-mediated hepatic inflammation and liver damage. Although there is...

Keywords

Nitric Oxide Liver Fibrosis Autoimmune Hepatitis Hepatic Inflammation Fibrosis Progression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

None.

References

  1. 1.
    Efe C, Kav T, Aydin C, et al. Low serum vitamin D levels are associated with severe histological features and poor response to therapy in patients with autoimmune hepatitis. Dig Dis Sci. 2014;59:3035–3042.CrossRefPubMedGoogle Scholar
  2. 2.
    Codoñer-Franch P, Tavárez-Alonso S, Simó-Jordá R, Laporta-Martín P, Carratalá-Calvo A, Alonso-Iglesias E. Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children. J Pediatr. 2012;161:848–854.CrossRefPubMedGoogle Scholar
  3. 3.
    Seydel S, Beilfuss A, Kahraman A, et al. Vitamin D ameliorates stress ligand expression elicited by free fatty acids in the hepatic stellate cell line LX-2. Turk J Gastroenterol. 2011;22:400–407.PubMedGoogle Scholar
  4. 4.
    Salum E, Kals J, Kampus P, et al. Vitamin D reduces deposition of advanced glycation end-products in the aortic wall and systemic oxidative stress in diabetic rats. Diabetes Res Clin Pract. 2013;100:243–249.CrossRefPubMedGoogle Scholar
  5. 5.
    Asemi Z, Samimi M, Tabassi Z, Shakeri H, Esmaillzadeh A. Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. J Nutr. 2013;143:1432–1438.CrossRefPubMedGoogle Scholar
  6. 6.
    Tanaka M, Tokunaga K, Komaba H, et al. Vitamin D receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism. Ther Apher Dial. 2011;15:161–168.CrossRefPubMedGoogle Scholar
  7. 7.
    Longhi MS, Ma Y, Mieli-Vergani G, Vergani D. Aetiopathogenesis of autoimmune hepatitis. J Autoimmun. 2010;34:7–14.CrossRefPubMedGoogle Scholar
  8. 8.
    Pemberton PW, Aboutwerat A, Smith A, Burrows PC, McMahon RF, Warnes TW. Oxidant stress in type I autoimmune hepatitis: the link between necroinflammation and fibrogenesis? Biochim Biophys Acta. 2004;1689:182–189.CrossRefPubMedGoogle Scholar
  9. 9.
    Snyder CM, Shroff EH, Liu J, Chandel NS. Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members. PLoS ONE. 2009;4:e7059.CrossRefPubMedCentralPubMedGoogle Scholar
  10. 10.
    Kim YM, Chung HT, Simmons RL, Billiar TR. Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition. J Biol Chem. 2000;275:10954–10961.CrossRefPubMedGoogle Scholar
  11. 11.
    Beyazit Y, Kocak E, Tanoglu A, et al. Oxidative stress might play a role in low serum vitamin D associated liver fibrosis among patients with autoimmune hepatitis. Dig Dis Sci. (Epub ahead of print). doi: 10.1007/s10620-015-3526-y.
  12. 12.
    Smyk DS, Orfanidou T, Invernizzi P, et al. Vitamin D in autoimmune liver disease. Clin Res Hepatol Gastroenterol. 2013;37:535–545.CrossRefPubMedGoogle Scholar
  13. 13.
    Czaja AJ. Hepatic inflammation and progressive liver fibrosis in chronic liver disease. World J Gastroenterol. 2014;20:2515–2532.CrossRefPubMedCentralPubMedGoogle Scholar
  14. 14.
    Sanz-Cameno P, Medina J, García-Buey L, et al. Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis. J Hepatol. 2002;37:723–729.CrossRefPubMedGoogle Scholar
  15. 15.
    Beyazit Y, Efe C, Tanoglu A, et al. Nitric oxide is a potential mediator of hepatic inflammation and fibrogenesis in autoimmune hepatitis. Scand J Gastroenterol. 2014. doi: 10.3109/00365521.2014.974203.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Yavuz Beyazit
    • 1
  • Erdem Kocak
    • 1
  • Alpaslan Tanoglu
    • 2
  • Murat Kekilli
    • 3
  1. 1.Department of GastroenterologyCanakkale State HospitalCanakkaleTurkey
  2. 2.Department of GastroenterologyGATA Haydarpasa Training HospitalUskudar, IstanbulTurkey
  3. 3.Department of GastroenterologyAnkara Education and Research HospitalAnkaraTurkey

Personalised recommendations