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Digestive Diseases and Sciences

, Volume 59, Issue 7, pp 1509–1512 | Cite as

Celiac Disease Is Diagnosed Less Frequently in Young Adult Males

  • Rohit Dixit
  • Benjamin Lebwohl
  • Jonas F. Ludvigsson
  • Suzanne K. Lewis
  • Norelle Rizkalla-Reilly
  • Peter H. R. Green
Original Article

Abstract

Background

The female predominance in celiac disease is difficult to explain because population-based screening studies reveal similar rates for celiac disease-specific autoantibodies in males and females.

Aim

The aim of this study was to explore the role of age and gender in the presentation of celiac disease.

Methods

The frequency of presentation according to age, gender and mode of presentation was determined by analysis of a prospectively maintained database of children and adults seen at a tertiary medical center.

Results

Of 1,682 patients (68 % female) aged 3 months to 86 years who were diagnosed with celiac disease, age at diagnosis in females peaked at 40–45 years, whereas the age at diagnosis for males had two peaks: 10–15 and 35–40 years. A significantly lower percentage of males in early adulthood were diagnosed compared with males in all other age groups (P < 0.0001). The young and elderly had a more even gender distribution.

Conclusions

Based on our analysis, males are diagnosed with celiac disease less frequently than females, especially in early adulthood. There should be more emphasis on the diagnosis of celiac disease among young adult males.

Keywords

Celiac disease Gender Diagnosis Epidemiology 

Notes

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Rohit Dixit
    • 1
  • Benjamin Lebwohl
    • 1
  • Jonas F. Ludvigsson
    • 3
    • 4
  • Suzanne K. Lewis
    • 1
  • Norelle Rizkalla-Reilly
    • 2
  • Peter H. R. Green
    • 1
    • 5
  1. 1.Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  2. 2.Department of Pediatrics, Celiac Disease Center, Columbia University College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  3. 3.Clinical Epidemiology Unit, Department of MedicineKarolinska University Hospital–Karolinska InstitutetStockholmSweden
  4. 4.Department of PediatricsÖrebro University HospitalÖrebroSweden
  5. 5.NewYork-Presbyterian HospitalNew YorkUSA

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