Digestive Diseases and Sciences

, Volume 59, Issue 2, pp 242–258 | Cite as

Measures to Reduce Mother-to-Child Transmission of Hepatitis B Virus in China: A Meta-Analysis

  • Hua Xu
  • Teng Zeng
  • Jun-Ying Liu
  • Yu Lei
  • Shan Zhong
  • Yun-Jian Sheng
  • Zhi Zhou
  • Hong Ren



Mother-to-child transmission (MTCT) is the main mode of spread of hepatitis B virus (HBV) in China. We performed a meta-analysis to compare the effects of three measures for prevention of MTCT.


A meta-analysis was performed on randomized controlled trials and non-randomized studies comparing the index of MTCT among five groups of pregnant women: hepatitis B immunoglobulin (HBIG) administration, antiviral treatment, placebo, elective caesarean section, and vaginal delivery.


Compared with the control group, the incidence of HBV intrauterine infection (RR = 0.42, 95 % CI 0.27–0.64, P < 0.0001) and the number of chronic hepatitis B (CHB) infants (RR = 0.44, 95 % CI 0.32–0.61, P < 0.00001) were lower in the HBIG administration group. In the antiviral treatment group, serum HBV DNA levels were lower (MD = −4.01, 95 % CI −5.07 to −2.94, P < 0.00001) at the time of delivery, and normalization of ALT levels was better (RR = 1.11, 95 % CI 1.06–1.17, P < 0.0001). Infant serum HBsAg positivity (RR = 0.45, 95 % CI 0.22–0.91, P = 0.03) and incidence of infant HBV transmission RR = 0.06, 95 % CI 0.01–0.24, P < 0.0001) were reduced in antiviral the treatment group. Infant serum anti-HBs positivity at birth (RR = 1.24, 95 % CI 0.89–1.74, P = 0.2) or at 6–7 months (RR = 0.98, 95 % CI 0.86–1.11, P = 0.73) was not significantly different between the caesarean section and vaginal delivery groups. The incidence of infant CHB infection may have been higher in the vaginal delivery group (RR = 2.20, 95 % CI 1.02–4.74, P = 0.04).


Administration of HBIG or antiviral therapy to HBV carrier mothers during pregnancy is effective in reducing MTCT.


Hepatitis B virus Mother-to-child transmission Reduce Meta-analysis 



Zhi Zhou conceived the study, provided funding support, and revised the manuscript critically for important intellectual content. Hua Xu made substantial contributions to the design of the study and to acquisition, analysis, and interpretation of the data. Teng Zeng, Jun-Ying Liu, Yu Lei, Shan Zhong, Yun-Jian Sheng, and Hong Ren participated in the design of the study and in acquisition, analysis, and interpretation of data. All authors read and approved the final manuscript. This work was supported by National Nature Science Foundation of China (grant numbers 81171563 and 31000397).

Conflict of interest


Supplementary material

10620_2013_2918_MOESM1_ESM.doc (60 kb)
Supplementary material 1 (DOC 60 kb)


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hua Xu
    • 1
  • Teng Zeng
    • 1
    • 2
  • Jun-Ying Liu
    • 1
    • 3
  • Yu Lei
    • 1
    • 2
  • Shan Zhong
    • 1
    • 2
  • Yun-Jian Sheng
    • 1
    • 2
  • Zhi Zhou
    • 1
    • 2
  • Hong Ren
    • 1
    • 2
  1. 1.The Second College of Clinical MedicineThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina
  2. 2.Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of EducationSecond Affiliated Hospital of Chongqing Medical UniversityChongqingChina
  3. 3.Department of the Digestive SystemZhou Kou Central HospitalZhoukouChina

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