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Digestive Diseases and Sciences

, Volume 59, Issue 1, pp 72–77 | Cite as

Nitric Oxide Synthase Gene Polymorphisms in Functional Dyspepsia

  • Jae Myung Park
  • Myong-Ki Baeg
  • Chul-Hyun Lim
  • Yu Kyung Cho
  • Myung-Gyu Choi
Original Article

Abstract

Objective

Nitrinergic control is important in meal-induced satiety. The aim of this study was to assess functional polymorphisms in nitric oxide synthase (NOS) genes in the susceptibility to functional dyspepsia (FD).

Methods

Genomic DNA from 89 patients with FD and 180 healthy subjects matched for age and gender were typed for the gene of neuronal NOS (nNOS, rs2682826), inducible NOS (iNOS, rs2297518) and a variable number tandem repeat in intron 4 of endothelial NOS (eNOS). Patients ingested 500 mL of Ensure® during a 20 min period and dyspeptic symptoms were scored.

Results

Genotype frequencies of eNOS and iNOS were not significantly different between FD patients and controls. The frequency of the T allele in nNOS was significantly higher in FD patients compared to the controls (49 vs. 16 %; odds ratio 5.01; 95 % confidence interval 2.83–9.01; p < 0.05). Patients with the T allele in the nNOS polymorphism reported a higher satiation score than those with the CC genotype during the nutrition drink test (median 179 vs. 117; p < 0.05).

Conclusion

The nNOS gene polymorphism is associated with susceptibility to FD and influences satiation in FD patients. Our data support the importance of NOS gene polymorphisms in the pathogenesis of FD.

Keywords

Functional dyspepsia Nitric oxide synthase Accommodation Polymorphism 

Notes

Acknowledgments

This work was partly supported by the National Research Foundation of Korea (NRF-2012-0006673).

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jae Myung Park
    • 1
  • Myong-Ki Baeg
    • 1
  • Chul-Hyun Lim
    • 1
  • Yu Kyung Cho
    • 1
  • Myung-Gyu Choi
    • 1
  1. 1.Department of Internal MedicineThe Catholic University of Korea College of MedicineSeoulKorea

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