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Digestive Diseases and Sciences

, Volume 58, Issue 10, pp 3057–3058 | Cite as

Fecal Occult Blood Test and Colorectal Cancer: Validation Study with Special Reference to False-Negative Patients

  • Tomoyuki Kawada
Correspondence
  • 192 Downloads

To the Editor,

Hewitson et al. [1] identified nine controlled trials involving over 320,000 participants with follow-up ranging from 8 to 18 years. They reported that screening using the fecal occult blood test (FOBT) resulted in a 25 % risk reduction [relative risk = 0.75, 95 % confidence interval (CI) 0.66–0.84] in colorectal cancer (CRC) mortality. They speculated that the screening yielded a beneficial reduction in cancer incidence and allowed earlier treatment of CRC. Despite the potential psychological impact of a false-positive result and complications of colonoscopy as the secondary screening procedure or a false-negative (FN) result, screening for CRC by the FOBT is accepted as a useful procedure [2].

Half et al. [3] recently evaluated the screening failure of FOBT for CRC, targeting patients with a FN result of FOBT. They identified 401 patients with CRC, and compared the survival between patients with a positive test result by a repeated FOBT and a persistently negative...

Keywords

Clopidogrel Peptic Ulcer Disease Fecal Occult Blood Test Microcytic Anemia Positive Fecal Occult Blood Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Hygiene and Public HealthNippon Medical SchoolBunkyōJapan

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