Digestive Diseases and Sciences

, Volume 58, Issue 10, pp 3057–3058 | Cite as

Fecal Occult Blood Test and Colorectal Cancer: Validation Study with Special Reference to False-Negative Patients

  • Tomoyuki Kawada

To the Editor,

Hewitson et al. [1] identified nine controlled trials involving over 320,000 participants with follow-up ranging from 8 to 18 years. They reported that screening using the fecal occult blood test (FOBT) resulted in a 25 % risk reduction [relative risk = 0.75, 95 % confidence interval (CI) 0.66–0.84] in colorectal cancer (CRC) mortality. They speculated that the screening yielded a beneficial reduction in cancer incidence and allowed earlier treatment of CRC. Despite the potential psychological impact of a false-positive result and complications of colonoscopy as the secondary screening procedure or a false-negative (FN) result, screening for CRC by the FOBT is accepted as a useful procedure [2].

Half et al. [3] recently evaluated the screening failure of FOBT for CRC, targeting patients with a FN result of FOBT. They identified 401 patients with CRC, and compared the survival between patients with a positive test result by a repeated FOBT and a persistently negative...


Clopidogrel Peptic Ulcer Disease Fecal Occult Blood Test Microcytic Anemia Positive Fecal Occult Blood Test 
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Conflict of interest



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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Hygiene and Public HealthNippon Medical SchoolBunkyōJapan

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