Fecal Occult Blood Test and Colorectal Cancer: Validation Study with Special Reference to False-Negative Patients
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To the Editor,
Hewitson et al.  identified nine controlled trials involving over 320,000 participants with follow-up ranging from 8 to 18 years. They reported that screening using the fecal occult blood test (FOBT) resulted in a 25 % risk reduction [relative risk = 0.75, 95 % confidence interval (CI) 0.66–0.84] in colorectal cancer (CRC) mortality. They speculated that the screening yielded a beneficial reduction in cancer incidence and allowed earlier treatment of CRC. Despite the potential psychological impact of a false-positive result and complications of colonoscopy as the secondary screening procedure or a false-negative (FN) result, screening for CRC by the FOBT is accepted as a useful procedure .
Half et al.  recently evaluated the screening failure of FOBT for CRC, targeting patients with a FN result of FOBT. They identified 401 patients with CRC, and compared the survival between patients with a positive test result by a repeated FOBT and a persistently negative...
KeywordsClopidogrel Peptic Ulcer Disease Fecal Occult Blood Test Microcytic Anemia Positive Fecal Occult Blood Test
Conflict of interest
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