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Digestive Diseases and Sciences

, Volume 58, Issue 10, pp 2784–2788 | Cite as

Multiple Hepatic Adenomas in a Child with Microvillus Inclusion Disease

  • Jennifer C. Burgis
  • C. Allan Pratt
  • John P. T. Higgins
  • John A. Kerner
Stanford Multidisciplinary Seminars

Case Presentation and Evolution

The patient, who was born full term to non-consanguineous parents following a pregnancy complicated only by polyhydramnios, was admitted with severe dehydration, weight loss and diarrhea on the sixth day of life. His electrolytes were significant for sodium 149 mmol/L, potassium 5 mmol/L, chloride 130 mmol/L, and bicarbonate 4.5 mmol/L. For the next 2 months, he suffered recurrent episodes of sepsis and suspected necrotizing enterocolitis. His stool output was secretory and large volume, ranging from 100 to 200 ml/kg/day, and did not change with cessation of enteral feeds. Workup included stool cultures and serum titers negative for enteric bacteria, viral and parasitic infections, normal inflammatory markers, normal immunoglobulins and complement, normal gastrin and urine catecholamines. An endoscopic biopsy at 3 months of life showed total atrophy of the intestinal villi. Periodic acid-Schiff staining revealed targetoid structures in the cytoplasm of...

Keywords

Adenoma Total Parenteral Nutrition Glycogen Storage Disease Galactosemia Hepatocellular Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jennifer C. Burgis
    • 1
  • C. Allan Pratt
    • 1
  • John P. T. Higgins
    • 2
  • John A. Kerner
    • 1
  1. 1.Division of Gastroenterology, Hepatology and Nutrition, Department of PediatricsLucile Packard Children’s Hospital at Stanford, Stanford University Medical CenterPalo AltoUSA
  2. 2.Department of PathologyLucile Packard Children’s Hospital at Stanford, Stanford University Medical CenterPalo AltoUSA

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