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Digestive Diseases and Sciences

, Volume 58, Issue 7, pp 1830–1837 | Cite as

Helicobacter pylori CagA: A Critical Destroyer of the Gastric Epithelial Barrier

  • Jia Wu
  • Song Xu
  • Yongliang Zhu
Review

Abstract

The destruction of the integrity of the gastric epithelial barrier underlies the pathology of many gastric diseases, including gastric tumors. The Helicobacter pylori virulence factor CagA is one of the main destroyers of the gastric epithelial barrier. There are differences among CagA proteins that originate from different isolates. CagA translocated into the gastric epithelial cells causes significant changes in cell signaling pathways in phosphorylation-dependent and phosphorylation-independent manners, leading to cell morphological changes and host cell epithelial barrier injury, which lay the foundation for the occurrence of related diseases. As a newly identified pathogenic mechanism of CagA, miRNA is involved in the remodeling of the gastric epithelial barrier. Both the eradication of H. pylori infection and interventions against CagA-induced gastric epithelial barrier lesions may contribute to the prevention of the development of gastric tumors.

Keywords

Helicobacter pylori CagA Gastric epithelial barrier Gastric diseases 

Notes

Acknowledgments

This work was supported by grants from the National Science of Foundation Committee of China (81071768, 31090361), the Natural Science of Foundation of Zhejiang Province (R2090074, Y2110246) and the Foundation of Scientific Technology Bureau of Zhejiang Province (2010C33118, 2011C23091).

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of GastroenterologySecond Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina

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