Fat Mass and Obesity-Associated Gene Enhances Oxidative Stress and Lipogenesis in Nonalcoholic Fatty Liver Disease
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Background and Aim
Nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity, hyperlipidemia, and type 2 diabetes mellitus. Several studies have found that fat mass and the obesity-associated (FTO) gene is linked to obesity. The aim of this work is to investigate the expression and function of FTO in liver with lipid metabolism diseases.
We investigated the basal FTO expression in an NAFLD rat model and compared it with control subjects. The function of FTO in lipid metabolism was further studied in L02 cells through overexpression experiments.
A significant increase in FTO mRNA and protein levels was found in the NAFLD group. In addition, the FTO levels were positively associated with malondialdehyde and superoxide dismutase concentrations. FTO overexpression in L02 cells enhanced lipogenesis and oxidative stress.
This study demonstrates that increased FTO levels in the liver are involved in oxidative stress and lipid deposition, which characterize NAFLD.
KeywordsFat mass and obesity-associated gene (FTO) Nonalcoholic fatty liver disease (NAFLD) Oxidative stress Lipogenesis
This work was supported by National Natural Science Foundation of China (30971405, 81170252, 81070656), the National Basic Research Program of China (2010CB535008, 973 Program), Medical Academic Key Talent Program of Jiangsu Province in China (2007200), the Jiangsu Province Innovation Project for Graduate Students of China (CXZZ11_0708), the China Postdoctoral Science Foundation (2012M510850) and Shanghai Postdoctoral Sustentation Fund (12R21414700).
Conflict of interest