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Safety and Effectiveness of Low-Dose Propofol Sedation During and After Esophagogastroduodenoscopy in Child A and B Cirrhotic Patients

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Abstract

Background

Effective and safe sedation for patients with liver cirrhosis is problematic.

Aim

To examine the safety and effectiveness of low-dose propofol sedation during and after esophagogastroduodenoscopy (EGD) in cirrhotic patients.

Methods

Study 1 was a prospective study in cirrhotic patients who underwent diagnostic EGD under propofol sedation. Propofol was given by bolus injection with an age-adjusted standard protocol consisting of 40 mg for patients <70 years, 30 mg for patients aged 70–89 years; additional injections of 20 mg propofol were given up to a maximum of 120 mg. The principal parameter was the occurrence of adverse events within 24 h after EGD. Secondary parameters included successful procedures, complications, and full recovery within 60 min. In Study 2, the residual effects of propofol were evaluated using a driving simulator and blood propofol concentrations in a subset of cirrhotic patients undergoing EGD and compared with healthy individuals. The principal parameter was driving ability.

Results

Study 1: Consecutive cirrhotic patients were entered and all 163 successfully completed EGD. The mean dose of propofol was 46 mg (range 30–120 mg). No complications occurred. Full recovery had occurred in 100 % 60 min after the procedure. No adverse events occurred within 24 h after EGD. Study 2: There were no significant differences in blood propofol levels between cirrhotic patients (n = 21) and healthy individuals (n = 20) after sedation. In cirrhotic patients, there was no deterioration in driving ability as compared with healthy individuals.

Conclusion

Low-dose propofol sedation provided safe and effective sedation for EGD in cirrhotic patients with rapid recovery.

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Abbreviations

EGD:

Esophagogastroduodenoscopy

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Acknowledgment

The authors thank David Y. Graham, MD, for his editorial advice.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Shinshu, Japan

    Naoki Tanaka & Toshifumi Aoyama

  2. Department of Gastroenterology, Shinshu University School of Medicine, Shinshu, Japan

    Naoki Tanaka & Eiji Tanaka

  3. Digestive Disease Center, Showa Inan General Hospital, 3230 Akaho, Komagane, 399-4117, Japan

    Akira Horiuchi, Yoshiko Nakayama & Masatsugu Isobe

  4. Division of Pharmacy, Shinshu University Hospital, Shinshu, Japan

    Yoshihiko Katsuyama & Shigeru Ohmori

Authors
  1. Naoki Tanaka
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  2. Akira Horiuchi
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  3. Yoshiko Nakayama
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  4. Yoshihiko Katsuyama
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  5. Masatsugu Isobe
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  6. Toshifumi Aoyama
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  7. Eiji Tanaka
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  8. Shigeru Ohmori
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Corresponding author

Correspondence to Akira Horiuchi.

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Tanaka, N., Horiuchi, A., Nakayama, Y. et al. Safety and Effectiveness of Low-Dose Propofol Sedation During and After Esophagogastroduodenoscopy in Child A and B Cirrhotic Patients. Dig Dis Sci 58, 1383–1389 (2013). https://doi.org/10.1007/s10620-012-2483-y

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  • DOI: https://doi.org/10.1007/s10620-012-2483-y

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