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Digestive Diseases and Sciences

, Volume 57, Issue 12, pp 3303–3306 | Cite as

Histologically Confirmed IgG4-Related Small Intestinal Lesions Diagnosed via Double Balloon Enteroscopy

  • Kyohei Fujita
  • Makoto Naganuma
  • Eiko Saito
  • Shinji Suzuki
  • Akihiro Araki
  • Mariko Negi
  • Hiroshi Kawachi
  • Mamoru Watanabe
Case Report

Immunoglobulin G4 (IgG4)-related disease is a systemic disease characterized by chronic inflammation with abundant IgG4-positive cells and elevated serum IgG4. Previous reports describe infiltration of IgG4-positive cells in multiple organs [1]. In the gastrointestinal (GI) tract, previous reports indicate that inflammation was observed in the esophagus, stomach, and colon [1, 2, 3, 4, 5, 6]. However, there have been few reports regarding small intestinal lesions. We report a case of IgG4-related disease with small and large intestinal lesions.

A 55-year-old man presented to our hospital with 4 months of general fatigue and lower abdominal pain. He had the past history of cholecystectomy and did not take any non-steroidal anti-inflammatory drugs. He was admitted because his abdominal pain was worsening. The findings of abdominal computed tomography (CT) scan indicated that his pancreas was swollen; however, he did not have any ocular, salivary gland, and retroperitoneal lesions. Blood...

Keywords

IgG4-related disorder Small intestinal lesion Balloon assist enteroscopy Immunohistochemistry 

Notes

Acknowledgments

The authors would like to express thanks to Dr Joseph Onyiah for giving us fruitful comments and editing the English language.

Conflict of interest

None.

References

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Kyohei Fujita
    • 1
  • Makoto Naganuma
    • 1
  • Eiko Saito
    • 1
  • Shinji Suzuki
    • 1
  • Akihiro Araki
    • 1
  • Mariko Negi
    • 2
  • Hiroshi Kawachi
    • 2
  • Mamoru Watanabe
    • 1
  1. 1.Departments of Gastroenterology and Hepatology, School of MedicineTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of Pathology, School of MedicineTokyo Medical and Dental UniversityTokyoJapan

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