Advertisement

Digestive Diseases and Sciences

, Volume 57, Issue 6, pp 1729–1731 | Cite as

A Comment on “Enteroendocrine and Neuronal Mechanisms in Pathophysiology of Acute Infectious Diarrhea” by Camilleri, Nullens and Nelsen

  • Michael L. Lucas
Correspondence

Dear Sir,

I read with interest the recent review, “Enteroendocrine and neuronal mechanisms in pathophysiology of acute infectious diarrhea” by Camilleri (DOI:  10.1007/s10620-011-1939-9), Nullens and Nelsen, which mentions my view of enterocyte secretion [1] as a “doctrine untroubled by proof.” While their introduction is commendably balanced, they then interpret past work from a position of accepting the enterocyte secretion hypothesis. May I offer some observations on the review in which I believe the reviewers have erred in interpretation?

The authors imply that the available in vitro evidence, excepting one knock-out mouse study, supports enterocyte secretion, but that some in vivo evidence [2] does not. My review emphasises that there is no in vitro evidence that withstands scrutiny. Ignoring this lack of proof invites reconciliation of in vitro data that cannot report on secretion with in vivo data from techniques that also do not necessarily measure net fluid secretion,...

Keywords

Hexamethonium Chloride Secretion Intestinal Secretion Interstitial Volume Acute Infectious Diarrhea 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Lucas ML. Diarrhoeal disease through enterocyte secretion: a doctrine untroubled by proof. Exp Physiol. 2010;95:479–484.PubMedCrossRefGoogle Scholar
  2. 2.
    Lucas ML, Thom MMM, Bradley JM, O’Reilly NF, McIlvenny TJ, Nelson YB. Escherichia coli heat stable (STa) enterotoxin and the upper small intestine: lack of evidence in vivo for net fluid secretion. J Mem Biol. 2005;206:29–42.CrossRefGoogle Scholar
  3. 3.
    Lucas ML. Amendments to the theory underlying Ussing chamber data of chloride ion secretion after bacterial enterotoxin exposure. J Theor Biol. 2005;234:21–37.PubMedCrossRefGoogle Scholar
  4. 4.
    Lucas ML, Duncan NW, O’Reilly NF, McIlvenny TJ, Nelson YB. Lack of remote vagally-mediated restoration of Escherichia coli enterotoxin (STa) inhibited fluid absorption from rat proximal jejunum. Neurogastroenterol Motil. 2008;20:532–538.PubMedCrossRefGoogle Scholar
  5. 5.
    Eklund S, Jodal M, Lundgren O. The enteric nervous system participates in the secretory response to the heat stable enterotoxins of Escherichia coli in rats and cats. Neuroscience. 1985;14:673–681.PubMedCrossRefGoogle Scholar
  6. 6.
    Wallentin I. Importance of tissue pressure for the fluid equilibrium between vascular and interstitial compartments in small intestine. Acta Physiol Scand. 1966;68:304–315.CrossRefGoogle Scholar
  7. 7.
    Johnson PC, Hanson KM. Effect of arterial pressure on arterial and venous resistance of intestine. J Appl Physiol. 1962;17:503–508.PubMedGoogle Scholar
  8. 8.
    Cassuto J, Jodal M, Tuttle R, Lundgren O. 5-Hydroxytryptamine and cholera secretion. Scand J Gastroenterol. 1982;17:695–703.PubMedCrossRefGoogle Scholar
  9. 9.
    MacLean LD, Brackney EL, Visscher MB. Effects of epinephrine, norepinephrine and histamine on canine intestine and liver weight continuously recorded in vivo. J Appl Physiol. 1956;9:237–240.PubMedGoogle Scholar
  10. 10.
    Granger DN, Richardson PDI, Taylor AE. Volumetric assessment of the capillary filtration coefficient in the cat small intestine. Pfluegers Arch. 1979;381:25–33.CrossRefGoogle Scholar
  11. 11.
    Eklund S, Jodal M, Lundgren O. The net fluid secretion caused by cyclic 3‘5‘-guanosine monophosphate in the rat jejunum in vivo is mediated by a local nervous reflex. Acta Physiol Scand. 1986;128:57–63.PubMedCrossRefGoogle Scholar
  12. 12.
    Lucas ML, Tainsh PJ, McColl S, Kenward HL, Watson PC, Gilligan LC, Graham V, Nelson YB. The interaction of stretch, intraluminal pressure and E.coli heat stable (STa) enterotoxin on jejunal fluid absorption in the anaesthetised rat. Proc Physiol Soc. 2008;11:C87.Google Scholar
  13. 13.
    Kopic S, Murek M, Geibel JP. Commentary on “Diarrhoeal disease through enterocyte secretion: a doctrine untroubled by proof”. Exp Physiol. 2010;95:484–485.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.School of Life Sciences, College of Medicine, Veterinary and Life SciencesUniversity of GlasgowScotlandUK

Personalised recommendations