Digestive Diseases and Sciences

, Volume 57, Issue 6, pp 1729–1731 | Cite as

A Comment on “Enteroendocrine and Neuronal Mechanisms in Pathophysiology of Acute Infectious Diarrhea” by Camilleri, Nullens and Nelsen

  • Michael L. Lucas

Dear Sir,

I read with interest the recent review, “Enteroendocrine and neuronal mechanisms in pathophysiology of acute infectious diarrhea” by Camilleri (DOI:  10.1007/s10620-011-1939-9), Nullens and Nelsen, which mentions my view of enterocyte secretion [1] as a “doctrine untroubled by proof.” While their introduction is commendably balanced, they then interpret past work from a position of accepting the enterocyte secretion hypothesis. May I offer some observations on the review in which I believe the reviewers have erred in interpretation?

The authors imply that the available in vitro evidence, excepting one knock-out mouse study, supports enterocyte secretion, but that some in vivo evidence [2] does not. My review emphasises that there is no in vitro evidence that withstands scrutiny. Ignoring this lack of proof invites reconciliation of in vitro data that cannot report on secretion with in vivo data from techniques that also do not necessarily measure net fluid secretion,...


Hexamethonium Chloride Secretion Intestinal Secretion Interstitial Volume Acute Infectious Diarrhea 
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.School of Life Sciences, College of Medicine, Veterinary and Life SciencesUniversity of GlasgowScotlandUK

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