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Celiac Disease Is Associated with Neurological Syndromes

  • Oya Uygur-Bayramicli
  • A. Melih Ozel
Correspondence

We read with interest the manuscript by Weinstock et al. [1] in which they evaluated the relationship between celiac disease and restless legs syndrome (RLS). The authors reported the incidence of RLS among 85 patients with celiac disease as 35%, with prevalence of 25%, compared with 10% of spouses (P < 0.02), and in 79% of patients with RLS and celiac disease, neuromuscular symptoms began during or after onset of gastrointestinal symptoms. They also reported that iron deficiency was present in 40% of celiac patients with active RLS compared with 6% of patients without RLS (P < 0.001) and that after 6 months of a gluten-free diet, RLS symptoms improved in 50% of 28 patients. They concluded that screening for celiac disease in patients with RLS is important, because celiac disease is commonly an overlooked silent disease and may be a correctable factor for some patients with idiopathic RLS.

We would like to report two cases of silent celiac disease, with complaints of non-specific...

Keywords

Creatine Kinase Celiac Disease Myopathy Iron Deficiency Anemia Neurological Finding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Weinstock LB, Walters AS, Mullin GE, Duntley SP. Celiac disease is associated with restless legs syndrome. Dig Dis Sci. 2010;55:1667–1673.PubMedCrossRefGoogle Scholar
  2. 2.
    Ludvigsson JF, Olsson T, Ekborn A, Montgomery SM. A population-based study of coeliac disease, neurodegenerative and neuroinflammatory diseases. Aliment Pharmacol Ther. 2007;25:1317–1327.PubMedCrossRefGoogle Scholar
  3. 3.
    Hadjivassiliou M, Chattopadhyay AK, Grünewald RA, et al. Myopathy associated with gluten sensitivity. Muscle Nerve. 2007;35:443–450.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Gastroenterology, School of MedicineMaltepe UniversityMaltepe, IstanbulTurkey

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