Digestive Diseases and Sciences

, Volume 56, Issue 1, pp 183–187 | Cite as

Peripheral Arthritis in the Course of Inflammatory Bowel Diseases

  • İlhami Yüksel
  • Hilmi Ataseven
  • Ömer Başar
  • Seyfettin Köklü
  • İbrahim Ertuğrul
  • Aysel Ülker
  • Ülkü Dağlı
  • Nurgül Şaşmaz
Original Article



Musculoskeletal disorders are well-defined extra-intestinal manifestations of inflammatory bowel diseases (IBD). There is little data regarding the frequencies of IBD and extra-intestinal manifestations from Central and East Europe and Middle Eastern countries.


To determine the prevalence of peripheral arthritis in IBD and to document the relationship to other extra-intestinal manifestations.


Enrolled in the study were 357 patients who were diagnosed with IBD from December 2002 through January 2008. All of the patients underwent a detailed whole-body examination by a gastroenterologist and rheumatologist.


IBD-related peripheral arthritis (IBDPA) was found in 66 (18.5%) of the 357 patients (28.3% Crohn’s disease, 13.5% ulcerative colitis; p = 0.001 χ = 11.62). IBDPA was more frequent in female patients (60.6 vs. 39.4%, p = 0.000, χ = 11.12). In eight (12.1%) cases, IBDPA occurred before the onset of IBD. Acute self-limiting episodes, recurrences of the attacks, and persistent symptoms of arthritis were present in 40 (60.6%), 26 (39.3%), and 29 (45.7%) patients, respectively. Arthritis was symmetrical in 33 (50%) cases. Knees (65.2%) and ankles (62.1%) were the most commonly affected joints. Erythema nodosum and pyoderma gangrenosum were more common among patients with IBDPA than patients without it (p = 0.001, χ = 10.49, and p = 0.000 χ = 25.77, respectively).


IBDPA is a frequent extra-intestinal complication of IBD. Those of female gender and the presence of Crohn’s disease, erythema nodosum and pyoderma gangrenosum have a higher risk to develop IBDPA.


Inflammatory bowel disease Peripheral arthritis Extra-intestinal manifestations Ulcerative colitis Crohn’s disease 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • İlhami Yüksel
    • 1
    • 3
  • Hilmi Ataseven
    • 2
  • Ömer Başar
    • 1
  • Seyfettin Köklü
    • 1
  • İbrahim Ertuğrul
    • 2
  • Aysel Ülker
    • 2
  • Ülkü Dağlı
    • 2
  • Nurgül Şaşmaz
    • 2
  1. 1.Department of GastroenterologyDışkapı Yıldırım Beyazıt Education and Research HospitalAnkaraTurkey
  2. 2.Department of GastroenterologyTürkiye Yüksek İhtisas HospitalAnkaraTurkey
  3. 3.AnkaraTürkiye

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