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Digestive Diseases and Sciences

, Volume 56, Issue 1, pp 103–108 | Cite as

Influence of MDR1 Polymorphism on H. pylori-Related Chronic Gastritis

  • Tomomitsu Tahara
  • Tomoyuki Shibata
  • Hiromi Yamashita
  • Ichiro Hirata
  • Tomiyasu Arisawa
Original Article

Abstract

Background

There is evidence that changes in MDR1 function and/or expression contribute to the pathogenesis of inflammatory disorders of the gastrointestinal tract.

Aims

We aimed to investigate the effect of C3435T polymorphism of the MDR1 gene on histological chronic gastritis, and on the risk of peptic ulcer diseases.

Methods

Restriction fragment length polymorphism analysis was performed for polymorphisms at C3435T in the MDR1 gene in 556 cancer-free subjects including 116 gastric and 60 duodenal ulcers, and 380 non-ulcer subjects. Gastritis scores in the antrum were assessed according to the updated Sydney system in 384 subjects.

Results

We did not find a significant association between MDR1 genotype and gastritis scores in any of the 384 subjects. However, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in H. pylori-positive subjects (CC vs. T carrier: p = 0.0495). When the H. pylori positive subjects were divided according to generation, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in subjects more than 65 years of age (CC vs. T carrier: p = 0.03). Also, the MDR1 3435 TT genotype was significantly associated with a higher degree of atrophy and intestinal metaplasia in the same generation (atrophy, TT vs. C carrier: p = 0.038, intestinal metaplasia, TT vs. C carrier: p = 0.016). No association was found between MDR1 genotypes and risk of peptic ulcer diseases.

Conclusions

It appears that the C3435T polymorphism of MDR1 influences H. pylori-related inflammatory conditions in the stomach, especially in older subjects.

Keywords

Chronic gastritis MDR1 Polymorphism Stomach C3435T H. pylori 

Abbreviations

H. pylori

Helicobacter pylori

MDR1

Multidrug resistance 1

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Tomomitsu Tahara
    • 1
  • Tomoyuki Shibata
    • 1
  • Hiromi Yamashita
    • 1
  • Ichiro Hirata
    • 1
  • Tomiyasu Arisawa
    • 2
  1. 1.Department of GastroenterologyFujita Health University School of MedicineToyoakeJapan
  2. 2.Department of GastroenterologyKanazawa Medical UniversityUchinadamachiJapan

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