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Pyloric Resection and Delayed Gastric Liquid Emptying in Rats

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Abstract

Background

Surgical resection of the distal stomach impairs gastric emptying. Generally, pylorus and the antrum are removed in the distal gastrectomy, however, the pylorus is removed individually under specific circumstances. We focus on the relation between the pyloric resection and the gastric liquid emptying.

Aims

The present investigation aimed to explore the pylorectomy how to influence gastric liquid emptying in rats.

Methods

Pylorectomy and end-to-end gastroduodenal anastomosis were conducted in rats. Electrodes were implanted in the gastrointestinal serosal surface near the stoma. Total stomach, proximal stomach, distal stomach and duodenal liquid emptying, myoelectricities in the gastrointestinal tract near the stoma, and structures were examined with scintigraphy, electrode recording in vivo, and electron microscopy, respectively.

Results

Delayed total stomach and distal stomach emptying were found in pylorectomy rats (p < 0.001). However, there was no difference in the proximal stomach and the duodenal liquid emptying compared to the controls (p > 0.05). The myoelectricity of 3–5 cpm (cycles/min) in antrum and 10–12 cpm in duodenum were found in the controls and no retrograde or antegrade myoelectricities were recorded in the duodenum and antrum. High-frequency myoelectricities (tachygastria) were recorded in the antrum near the stoma (p < 0.01), the retrograde and antegrade myoelectricities propagating through the stoma were recorded, and the regenerated interstitial cells of Cajal were found in stoma under electron microscope observation in pylorectomy rat.

Conclusions

The gastroduodenal incoordination and abnormal myoelectricity related to impaired contraction in the antrum caused the delayed liquid gastric emptying in pylorectomy rats.

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Acknowledgments

We thank Dr. Bimal Kumarfor Sah for his contribution on organization of the manuscript. This study was supported by The Foundation of the Ministry of Education of China for Outstanding Young Teachers in University.

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Authors and Affiliations

  1. Department of General Surgery, Zhong-Da Hospital, Southeast University School of Medicine, 210009, Nanjing, China

    Cheng-Zhong You, Jing-Jun Sun, Jia-Quan Xiao, Hai-Quan Huang & Wen-Hao Tang

  2. Department of Physiology, Southeast University School of Medicine, 210009, Nanjing, China

    Rong Dong

  3. Nuclear Medicine Technology Institution of Southeast University, 210009, Nanjing, China

    Hai-Chuan Qu & Ming-Hua Du

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  1. Cheng-Zhong You
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Correspondence to Wen-Hao Tang.

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You, CZ., Dong, R., Sun, JJ. et al. Pyloric Resection and Delayed Gastric Liquid Emptying in Rats. Dig Dis Sci 56, 49–58 (2011). https://doi.org/10.1007/s10620-010-1238-x

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  • DOI: https://doi.org/10.1007/s10620-010-1238-x

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