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Digestive Diseases and Sciences

, Volume 56, Issue 1, pp 197–202 | Cite as

Intima-Media Thickness of the Common Carotid Artery Is Not Significantly Higher in Crohn’s Disease Patients Compared to Healthy Population

  • Efrat Broide
  • Andrei Schopan
  • Michael Zaretsky
  • Nimrod Alain Kimchi
  • Michael Shapiro
  • Eitan Scapa
Original Article

Abstract

Background

Patients with Crohn’s disease might have accelerated atherosclerosis due to: chronic systemic inflammation, metabolic changes or prolonged steroid treatment.

Aims

The aim of this study was to assess the risk of sub-clinical atherosclerosis in Crohn’s disease, by measuring the intima-media thickness and peak systolic velocity of the common carotid artery.

Methods

Fifty Crohn’s disease patients aged between 20 and 45 years were compared to 25 controls. Patients with a family history of cardiovascular diseases or a known risk for atherosclerosis were excluded. All participants underwent nutritional assessment. Carotid artery ultrasonography was performed and intima-media thickness and peak systolic velocity were measured, proximal to the common carotid bifurcation. Clinical data and laboratory parameters (hemoglobin, highly sensitive C-reactive protein, and plasma homocysteine) were determined.

Results

No significant differences between the groups were found for intima-media thickness or peak systolic velocity. Multiple regression analysis revealed a positive correlation of intima-media thickness with older age. Peak systolic velocity was negatively associated with age.

Conclusions

Crohn’s disease patients do not have an increased risk for developing early atherosclerosis.

Keywords

Crohn’s disease Atherosclerosis Intima-media thickness Peak systolic velocity 

Notes

Conflict of interest statement

None.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Efrat Broide
    • 1
    • 3
  • Andrei Schopan
    • 1
    • 3
  • Michael Zaretsky
    • 2
    • 3
  • Nimrod Alain Kimchi
    • 1
    • 3
  • Michael Shapiro
    • 1
    • 3
  • Eitan Scapa
    • 1
    • 3
  1. 1.Institute of Gastroenterology, Liver Diseases and NutritionAssaf Harofeh Medical CenterZerifinIsrael
  2. 2.Vascular LaboratoryAssaf Harofeh Medical CenterZerifinIsrael
  3. 3.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

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