Intima-Media Thickness of the Common Carotid Artery Is Not Significantly Higher in Crohn’s Disease Patients Compared to Healthy Population
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Patients with Crohn’s disease might have accelerated atherosclerosis due to: chronic systemic inflammation, metabolic changes or prolonged steroid treatment.
The aim of this study was to assess the risk of sub-clinical atherosclerosis in Crohn’s disease, by measuring the intima-media thickness and peak systolic velocity of the common carotid artery.
Fifty Crohn’s disease patients aged between 20 and 45 years were compared to 25 controls. Patients with a family history of cardiovascular diseases or a known risk for atherosclerosis were excluded. All participants underwent nutritional assessment. Carotid artery ultrasonography was performed and intima-media thickness and peak systolic velocity were measured, proximal to the common carotid bifurcation. Clinical data and laboratory parameters (hemoglobin, highly sensitive C-reactive protein, and plasma homocysteine) were determined.
No significant differences between the groups were found for intima-media thickness or peak systolic velocity. Multiple regression analysis revealed a positive correlation of intima-media thickness with older age. Peak systolic velocity was negatively associated with age.
Crohn’s disease patients do not have an increased risk for developing early atherosclerosis.
KeywordsCrohn’s disease Atherosclerosis Intima-media thickness Peak systolic velocity
Conflict of interest statement
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