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Digestive Diseases and Sciences

, Volume 55, Issue 5, pp 1272–1277 | Cite as

Oral Administration of Curcumin Emulsified in Carboxymethyl Cellulose Has a Potent Anti-inflammatory Effect in the IL-10 Gene-Deficient Mouse Model of IBD

  • Victoria Y. L. Ung
  • Rae R. Foshaug
  • Sarah M. MacFarlane
  • Thomas A. Churchill
  • Jason S. G. Doyle
  • Beate C. Sydora
  • Richard N. Fedorak
Original Article

Abstract

Curcumin is a tumeric-derived, water-insoluble polyphenol with potential beneficial health effects for humans. It has been shown to have preventive as well as therapeutic effects in chemically induced murine models of colitis. To investigate whether curcumin exerts a similar effect on the spontaneous colitis in interleukin (IL)-10 gene-deficient mice, we gavaged these mice daily for 2 weeks with 200 mg/kg per day curcumin emulsified in carboxymethyl cellulose, a food additive generally used as a viscosity modifier. Mice fed the curcumin/carboxymethyl cellulose mixture and those receiving carboxymethyl cellulose alone demonstrated similar reductions in histological injury score and colon weight/length ratio compared to water-fed controls. However, significant reductions in pro-inflammatory cytokine release in intestinal explant cultures were only seen in mice treated with the curcumin mixture. Our data demonstrate that in IL-10 gene-deficient mice, both oral curcumin and carboxymethyl cellulose, appear to have modifying effects on colitis. However, curcumin has additional anti-inflammatory effects mediated through a reduced production of potent pro-inflammatory mucosal cytokines.

Keywords

Carboxymethyl cellulose Curcumin Inflammatory bowel disease Interleukin-10 

Notes

Acknowledgments

This work was supported by a grant from the Crohn’s and Colitis Foundation of Canada.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Victoria Y. L. Ung
    • 1
  • Rae R. Foshaug
    • 1
  • Sarah M. MacFarlane
    • 1
  • Thomas A. Churchill
    • 2
  • Jason S. G. Doyle
    • 3
  • Beate C. Sydora
    • 1
  • Richard N. Fedorak
    • 1
  1. 1.Department of Medicine, Division of Gastroenterology, Center of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR)University of AlbertaEdmontonCanada
  2. 2.Department of SurgeryUniversity of AlbertaEdmontonCanada
  3. 3.Department of Laboratory Medicine and PathologyVernon Jubilee HospitalVernonCanada

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