Digestive Diseases and Sciences

, Volume 54, Issue 10, pp 2298–2299 | Cite as

Is Furazolidone Therapy for Helicobacter pylori Effective and Safe?

  • Vincenzo De Francesco
  • Enzo Ierardi
  • Cesare Hassan
  • Angelo Zullo

We have read with great interest the study performed in Pakistan by Abbas et al. [1] on the efficacy and safety of a “rescue” therapy to cure Helicobacter pylori infection. Briefly, following a quadruple therapy including high-dose esomeprazole, bismuth salts, amoxicillin-clavulanic acid, and furazolidone, an 81% eradication rate was achieved at ITT analysis, with a side-effects incidence as high as 50%. The authors concluded that “it is reasonably well tolerated and is an effective second-line regimen” and even suggested it could be used as a first-line therapy. We have some concerns about these conclusions. First, following the first-line therapy, H. pylorieradication was achieved in 119 (67.6%) out of 176 enrolled patients. Consequently, 57 eradication failure patients were available instead of 52, as was reported. If all these patients received a second-line therapy, then both ITT and PP analysis should be accordingly calculated. Second, the reported side-effects incidence (up to...


Bismuth Proton Pump Inhibitor Pylorus Infection Triple Therapy Esomeprazole 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Vincenzo De Francesco
    • 1
  • Enzo Ierardi
    • 1
  • Cesare Hassan
    • 2
  • Angelo Zullo
    • 2
  1. 1.Gastroenterology Unit“Riuniti” HospitalFoggiaItaly
  2. 2.Gastroenterology and Digestive EndoscopyNuovo Regina Margherita HospitalRomeItaly

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