Helicobacter pylori Infection as a Risk Factor for Insulin Resistance
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This study aimed to determine the relation between Helicobacter pylori infection and insulin resistance in healthy subjects. In a cross-sectional case control study between January and April 2007, a total of 71 healthy subjects without the exclusion criteria completed the study. Forty-three (60.6%) patients were H. pylori positive and 28 (39.4%) patients were H. pylori negative. Age and body mass index of the patients were not significantly different between the two groups (32.2 ± 14.2 vs. 33 ± 8.05 years and 23.15 ± 4.5 vs. 24.04 ± 3.2 kg/m2, respectively). H-pylori-positive patients had significantly higher HOMA-IR level compared to H-pylori-negative patients (3.54 ± 2.2 vs. 2.46 ± 1.9, respectively) (P < 0.05). Fasting serum insulin level was significantly higher in the H-pylori-positive group compared with the H-pylori-negative group (19.41 ± 3.08 vs. 16.57 ± 2.02 μU/ml, respectively) (P < 0.05). Our findings suggest recognition of H. pylori infection as a risk factor for insulin resistance.
KeywordsInsulin resistance Helicobacter pylori HOMA-IR Fasting serum insulin
The authors thank Dr. Gul Bank, Consultant Diabetes and Endocrinologist, and Dr. Debasish Bannerjee, Consultant Nephrologist, in the St. George’s Hospital, London, for their kind support in the review of this article.
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