The Association Between Obesity and GERD: A Review of the Epidemiological Evidence
- 557 Downloads
The current epidemics of obesity and gastroesophageal reflux disease (GERD)-related disorders have generated much interest in studying the association between them. Results of multiple studies indicate that obesity satisfies several criteria for a causal association with GERD and some of its complications, including a generally consistent association with GERD symptoms, erosive esophagitis, and esophageal adenocarcinoma. An increase in GERD symptoms has been shown to occur in individuals who gain weight but continue to have a body mass index (BMI) in the normal range, contributing to the epidemiological evidence for a possible dose–response relationship between BMI and increasing GERD. Data are less clear on the relationship between Barrett’s esophagus (BE) and obesity. However, when considered separately, abdominal obesity seems to explain a considerable part of the association with GERD, including BE. Overall, epidemiological data show that maintaining a normal BMI may reduce the likelihood of developing GERD and its potential complications.
KeywordsGastroesophageal reflux disease Obesity Body mass index Epidemiology
Dr. El-Serag has served as a consultant for TAP Pharmaceuticals, AstraZeneca, Eisai, and Novartis.
- 8.El-Serag HB (2002) The epidemic of esophageal adenocarcinoma. Gastroenterol Clin North Am 31:421–440Google Scholar
- 21.Ruhl CE, Everhart JE (1999) Overweight, but not high dietary fat intake, increases risk of gastroesophageal reflux disease hospitalization: the NHANES I Epidemiologic Followup Study. First National Health and Nutrition Examination Survey. Ann Epidemiol 9:424–435. doi: 10.1016/S1047-2797(99)00020-4 PubMedCrossRefGoogle Scholar
- 35.Corley DA, Kubo A, Levin TR, Block G, Habel L, Zhao W, Leighton P, Quesenberry C, Rumore GJ, Buffler PA (2007) Abdominal obesity and body mass index as risk factors for Barrett’s esophagus. Gastroenterology 133:34–41, quiz 311Google Scholar
- 47.Diaz-Rubio M, Moreno-Elola-Olaso C, Rey E, Locke GR 3rd, Rodiguez-Artalejo F (2004) Symptoms of gastro-oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population. Aliment Pharmacol Ther 19:95–105. doi: 10.1046/j.1365-2036.2003.01769.x PubMedCrossRefGoogle Scholar