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Digestive Diseases and Sciences

, Volume 53, Issue 9, pp 2564–2568 | Cite as

Persistence of Hepatitis C Virus in Peripheral Blood Mononuclear Cells of Sustained Viral Responders to Pegylated Interferon and Ribavirin Therapy

  • Juan F. Gallegos-Orozco
  • Jorge Rakela
  • Marianne J. Rosati
  • Hugo E. Vargas
  • Vijayan Balan
Original Article

Abstract

The aim of this paper was to assess the persistence of hepatitis C virus (HCV) among patients successfully treated with peginterferon and ribavirin. The persistence of viral RNA was evaluated in the serum and peripheral blood mononuclear cells (PBMCs) of 25 chronic hepatitis C patients with sustained viral response to peginterferon and ribavirin treatment up to 56 months after the completion of therapy. Viral RNA was detected in the peripheral blood mononuclear cell cultures of five patients (20%), but none had detectable serum HCV RNA. At present, the clinical relevance of this finding is unclear. It is possible that viral persistence and, specifically, the presence of HCV RNA in PBMCs may lead to HCV reactivation under special circumstances, such as immunosuppression.

Keywords

Viral hepatitis Hepatitis C virus Viral persistence Peripheral blood mononuclear cells Peginterferon 

Notes

Acknowledgments

This work was supported in part by a grant from the Palumbo Foundation, the Edson Foundation and Roche Laboratories. The study sponsors did not participate in the design of the study, collection, analysis, or interpretation of the data, and were not involved in the writing of the manuscript.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Juan F. Gallegos-Orozco
    • 1
  • Jorge Rakela
    • 2
  • Marianne J. Rosati
    • 2
  • Hugo E. Vargas
    • 2
  • Vijayan Balan
    • 2
  1. 1.Department of Internal MedicineMayo Clinic ArizonaPhoenixUSA
  2. 2.Division of Transplantation MedicineMayo Clinic ArizonaPhoenixUSA

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