Digestive Diseases and Sciences

, Volume 53, Issue 4, pp 977–981 | Cite as

Sarcoidosis in Patients with Celiac Disease

  • Elizabeth Hwang
  • Russell McBride
  • Alfred I. Neugut
  • Peter H. R. Green
Original Paper


Purpose Several case reports and European studies have suggested an association between sarcoidosis and celiac disease; however, they have been inconsistent. We therefore analyzed a large cohort of celiac-disease patients to assess this association. Methods An anonymized database of patients with celiac disease was reviewed to determine the number of patients with sarcoidosis. Age- and gender-adjusted standardized morbidity ratios with corresponding 95% confidence intervals (CI) were calculated by comparing results to US-population-derived prevalence data. Results Ten patients were found to have a comorbid diagnosis of sarcoidosis, representing an age- and gender-adjusted standardized morbidity ratio of 36.8 (95% CI 26.7–50.9). Conclusions In this cohort of patients with celiac disease, there was a significantly increased risk of sarcoidosis when compared with the American white population. This further strengthens prior associations that have been made suggesting a shared mechanism behind the etiologies of celiac disease and sarcoidosis.


Celiac disease Sarcoidosis Prevalence Etiology Autoimmunity 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Elizabeth Hwang
    • 1
  • Russell McBride
    • 2
  • Alfred I. Neugut
    • 2
  • Peter H. R. Green
    • 1
  1. 1.Department of MedicineColumbia University Medical CenterNew YorkUSA
  2. 2.Department of Epidemiology, Mailman School of Public HealthColumbia UniversityNew YorkUSA

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