Sarcoidosis in Patients with Celiac Disease
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Purpose Several case reports and European studies have suggested an association between sarcoidosis and celiac disease; however, they have been inconsistent. We therefore analyzed a large cohort of celiac-disease patients to assess this association. Methods An anonymized database of patients with celiac disease was reviewed to determine the number of patients with sarcoidosis. Age- and gender-adjusted standardized morbidity ratios with corresponding 95% confidence intervals (CI) were calculated by comparing results to US-population-derived prevalence data. Results Ten patients were found to have a comorbid diagnosis of sarcoidosis, representing an age- and gender-adjusted standardized morbidity ratio of 36.8 (95% CI 26.7–50.9). Conclusions In this cohort of patients with celiac disease, there was a significantly increased risk of sarcoidosis when compared with the American white population. This further strengthens prior associations that have been made suggesting a shared mechanism behind the etiologies of celiac disease and sarcoidosis.
KeywordsCeliac disease Sarcoidosis Prevalence Etiology Autoimmunity
- 7.Baughman RP, Teirstein AS, Judson MA, Rossman MD, Yeager H, Bresnitz EA, Depalo L, Hunnighake G, Iannuzzi MC, Johns CJ, Mclennan G, Moller DR, Newman LS, Rabin DL, Rose C, Rybicki B, Cherniak R, A Case Control Etiologic Study of Sarcoidosis (ACCESS) research group (2001) Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med 164:1885–1889PubMedGoogle Scholar
- 11.Henke CE, Henke G, Elveback LR, Beard CM, Ballard DJ, Kurland LT (1985) The epidemiology of sarcoidosis in Rochester, Minnesota: a population-based study of incidence and survival. Am J Epidemiol 123:840–845Google Scholar
- 12.Breslow NE, Day NE (1987) Statistical methods in cancer research: volume II – the design and analysis of cohort studies. IARC Scientific Publication, No 82, International Agency for Research on Cancer. Oxford University Press, New YorkGoogle Scholar
- 20.Reid JD (1998) Sarcoidosis in coroner’s autopsies: a critical evaluation in diagnosis and prevalence from Cuyahoga County, Ohio. Sarcoid Vascul Diffuse Lung Dis 15:44–51Google Scholar