Gastric Emptying is Altered with the Presence of Gastritis
Helicobacter pylori infection and gastritis can cause symptoms suggestive of altered gastrointestinal function; however, it is unclear if H. pylori influences gastric motility. This study assessed gastric emptying rates in mouse models of gastritis. Gastritis was induced in C57BL/6 mice via ethanol treatment or via challenge with H. pylori or H. felis. Gastric emptying rates of nutrient and non-nutrient liquids were assessed with the non-invasive 13C-breath test, and the results were compared to healthy mice. Gastric emptying of the non-nutrient liquid was unaltered with the presence of gastritis; however, gastric emptying of the nutrient liquid was accelerated after a 4-week infection with H. pylori. H. felis infection and ethanol treatment caused a more severe gastritis and disruptions to the normal gastric emptying. Changes to gastric emptying in mouse models of gastritis are associated with the presence of nutrients. Altered gastric emptying may contribute to symptoms commonly reported in humans with gastritis.
KeywordsGastritis Gastric emptying Helicobacter pylori 13C octanoic acid breath test
- 15.Ghoos Y, Maes B, Geypens B, Mys G, Hiele M, Rutgeerts P, Vantrappen G (1993) Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterol 104:1640–1647Google Scholar
- 16.Symonds E (2003) Non-invasive assessment of gastrointestinal function using breath test technology: investigations in health and disease. In Physiology Department. Adelaide, The University of AdelaideGoogle Scholar
- 21.Debas H, Farooq O, Grossman M (1975) Inhibition of gastric emptying is a physiological action of cholecystokinin. Gastroenterol 68:1211–1217Google Scholar