Advertisement

Digestive Diseases and Sciences

, Volume 53, Issue 3, pp 636–641 | Cite as

Gastric Emptying is Altered with the Presence of Gastritis

  • Erin L. Symonds
  • Cuong D. Tran
  • Ross N. Butler
  • Taher I. Omari
Original Paper

Abstract

Helicobacter pylori infection and gastritis can cause symptoms suggestive of altered gastrointestinal function; however, it is unclear if H. pylori influences gastric motility. This study assessed gastric emptying rates in mouse models of gastritis. Gastritis was induced in C57BL/6 mice via ethanol treatment or via challenge with H. pylori or H. felis. Gastric emptying rates of nutrient and non-nutrient liquids were assessed with the non-invasive 13C-breath test, and the results were compared to healthy mice. Gastric emptying of the non-nutrient liquid was unaltered with the presence of gastritis; however, gastric emptying of the nutrient liquid was accelerated after a 4-week infection with H. pylori. H. felis infection and ethanol treatment caused a more severe gastritis and disruptions to the normal gastric emptying. Changes to gastric emptying in mouse models of gastritis are associated with the presence of nutrients. Altered gastric emptying may contribute to symptoms commonly reported in humans with gastritis.

Keywords

Gastritis Gastric emptying Helicobacter pylori 13C octanoic acid breath test 

References

  1. 1.
    Saslow S, Thumshirn M, Camilleri M, Locke G, Thomforde G, Burton D, Hanson R (1998) Influence of H. pylori infection on gastric motor and sensory function in asymptomatic volunteers. Dig Dis Sci 43:258–264PubMedCrossRefGoogle Scholar
  2. 2.
    Testoni P, Bagnolo F, Masci E, Colombo E, Tittobello A (1993) Different interdigestive antroduodenal motility patterns in chronic antral gastritis with and without Helicobacter pylori infection. Dig Dis Sci 38:2255–2261PubMedCrossRefGoogle Scholar
  3. 3.
    Chiloiro M, Russo F, Riezzo G, Leoci C, Clemente C, Catrina M, Di Leo A (2001) Effect of Helicobacter pylori infection on gastric emptying and gastroinestinal hormones in dyspeptic and healthy subjects. Dig Dis Sci 46:46–53PubMedCrossRefGoogle Scholar
  4. 4.
    Duval-Araujo I, De Magal-Aes Queiroz D, Magnago A, Simal C, Marino VS, Carvalho S, Da Silva Machado L, Miranda D (2000) Increased gastric emptying induced by Helicobacter heilmannii type 1 infection in rats. J Med Microbiol 49:627–634PubMedGoogle Scholar
  5. 5.
    Goh K, Paramsothy M, Azian M, Parasakthi N, Peh S, Bux S, Lo Y, Ong K (1997) Does Helicobacter pylori infection affect gastric emptying in patients with functional dyspepsia. J Gastroenterol Hepatol 12:790–794PubMedGoogle Scholar
  6. 6.
    Konturek J, Stoll R, Menzel J, Konturek M, Konturek S, Domschke W (2001) Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients. Scand J Gastroenterol 36:241–246PubMedCrossRefGoogle Scholar
  7. 7.
    Okumura T, Shoji E, Takahashi N, Wakebe H, Imagawa K, Kikuchi M, Kohgo Y (1998) Delayed gastric emptying by Helicobacter pylori lipopolysaccharide in conscious rats. Dig Dis Sci 43:90–94PubMedCrossRefGoogle Scholar
  8. 8.
    Onuk M, Uslu H, Varoglu E (2001) Effects of eradication therapy on gastric emptying in patients with Helicobacter pylori-positive duodenal ulcers. J Int Med Res 29:178–180PubMedGoogle Scholar
  9. 9.
    Perri F, Ghoos Y, Maes B, Geypens B, Ectors N, Geboes K, Hiele M, Rutgeerts P (1996) Gastric emptying and Helicobacter pylori infection in duodenal ulcer disease. Dig Dis Sci 41:462–468PubMedCrossRefGoogle Scholar
  10. 10.
    Symonds E, Butler R, Omari T (2000) Assessment of gastric emptying in the mouse using the [13C]-octanoic acid breath test. Clin Exp Pharm Physiol 27:671–675CrossRefGoogle Scholar
  11. 11.
    Symonds E, Butler R, Omari T (2002) Noninvasive breath tests can detect alterations in gastric emptying in the mouse. Eur J Clin Invest 32:341–344PubMedCrossRefGoogle Scholar
  12. 12.
    Lee A, O’Rourke J, De Ungria M, Robertson B, Daskalopoulos G, Dixon M (1997) A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterol 112:1386–1397CrossRefGoogle Scholar
  13. 13.
    Howarth G, Francis G, Cool J, Xu X, Byard R, Read L (1996) Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J Nutr 126:2519–2530PubMedGoogle Scholar
  14. 14.
    Desai K, Sato R, Schauble E, Barsh G, Kobilka B, Bernstein D (1997) Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease. Am J Physiol 272:H1053–H1061PubMedGoogle Scholar
  15. 15.
    Ghoos Y, Maes B, Geypens B, Mys G, Hiele M, Rutgeerts P, Vantrappen G (1993) Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterol 104:1640–1647Google Scholar
  16. 16.
    Symonds E (2003) Non-invasive assessment of gastrointestinal function using breath test technology: investigations in health and disease. In Physiology Department. Adelaide, The University of AdelaideGoogle Scholar
  17. 17.
    Gledhill T, Leicester R, Addis B, Lightfoot N, Barnard J, Viney N, Darkin D, Hunt RH (1985) Epidemic hypochlorhydria. BMJ (Clin Res Ed) 290:1383–1386CrossRefGoogle Scholar
  18. 18.
    Mohammadi M, Redline R, Nedrud J, Czinn S (1996) Role of the host in pathogenesis of Helicobacter-associated gastritis: H. felis infection of inbred and congenic mouse strains. Infect Immun 64:238–245PubMedGoogle Scholar
  19. 19.
    Domínguez-Muñoz J, Malfertheiner P (2001) Effect of Helicobacter pylori infection on gastrointestinal motility, pancreatic secretion and hormone release in asymptomatic humans. Scand J Gastroenterol 36:1141–1147PubMedCrossRefGoogle Scholar
  20. 20.
    Murakami K, Fujioka T, Shiota K, Ito A, Fujiyama K, Kodama R, Kawasaki Y, Kubota T, Nasu M (1995) Influence of Helicobacter pylori infection and the effects of its eradication on gastric emptying in non-ulcerative dyspepsia. Eur J Gastroenterol Hepatol 7:S93–S97PubMedGoogle Scholar
  21. 21.
    Debas H, Farooq O, Grossman M (1975) Inhibition of gastric emptying is a physiological action of cholecystokinin. Gastroenterol 68:1211–1217Google Scholar
  22. 22.
    Moran T, Wirth J, Schwartz G, McHugh P (1999) Interactions between gastric volume and duodenal nutrients in the control of liquid gastric emptying. Am J Physiol 276:R997–R1002PubMedGoogle Scholar
  23. 23.
    Lee A (1995) Helicobacter infection in laboratory animals: a model for gastric neoplasias? Ann Med 27:575–582PubMedCrossRefGoogle Scholar
  24. 24.
    Maddern G, Horowitz M, Hetzel D, Jamieson G (1985) Altered solid and liquid gastric emptying in patients with duodenal ulcer disease. Gut 26:689–693PubMedCrossRefGoogle Scholar
  25. 25.
    Paraskevopoulos J, Houghton L, Eyre-Brooke I, Johnson A, Read N (1988) Effect of composition of gastric contents on resistance to emptying of liquids from stomach in humans. Dig Dis Sci 33:914–918PubMedCrossRefGoogle Scholar
  26. 26.
    Lee J, Camilleri M, Zinsmeister A, Burton D, Kost L, Klein P (2000) A valid, accurate, office based non-radioactive test for gastric emptying of solids. Gut 46:768–773PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Erin L. Symonds
    • 1
  • Cuong D. Tran
    • 1
  • Ross N. Butler
    • 1
    • 2
  • Taher I. Omari
    • 1
    • 2
  1. 1.Gastroenterology UnitChildren, Youth and Women’s Health ServiceNorth AdelaideSouth Australia
  2. 2.Department of PaediatricsThe University of AdelaideAdelaideSouth Australia

Personalised recommendations