Digestive Diseases and Sciences

, Volume 53, Issue 3, pp 636–641 | Cite as

Gastric Emptying is Altered with the Presence of Gastritis

  • Erin L. Symonds
  • Cuong D. Tran
  • Ross N. Butler
  • Taher I. Omari
Original Paper


Helicobacter pylori infection and gastritis can cause symptoms suggestive of altered gastrointestinal function; however, it is unclear if H. pylori influences gastric motility. This study assessed gastric emptying rates in mouse models of gastritis. Gastritis was induced in C57BL/6 mice via ethanol treatment or via challenge with H. pylori or H. felis. Gastric emptying rates of nutrient and non-nutrient liquids were assessed with the non-invasive 13C-breath test, and the results were compared to healthy mice. Gastric emptying of the non-nutrient liquid was unaltered with the presence of gastritis; however, gastric emptying of the nutrient liquid was accelerated after a 4-week infection with H. pylori. H. felis infection and ethanol treatment caused a more severe gastritis and disruptions to the normal gastric emptying. Changes to gastric emptying in mouse models of gastritis are associated with the presence of nutrients. Altered gastric emptying may contribute to symptoms commonly reported in humans with gastritis.


Gastritis Gastric emptying Helicobacter pylori 13C octanoic acid breath test 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Erin L. Symonds
    • 1
  • Cuong D. Tran
    • 1
  • Ross N. Butler
    • 1
    • 2
  • Taher I. Omari
    • 1
    • 2
  1. 1.Gastroenterology UnitChildren, Youth and Women’s Health ServiceNorth AdelaideSouth Australia
  2. 2.Department of PaediatricsThe University of AdelaideAdelaideSouth Australia

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